Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism

Feng Weiwei; Liu Yongchao; Fei Fan; Chen Yao; Ding Yangyang; Yan Mengjiao; Feng Yun; Zhao Ting; Mao Guanghua; Yang Liuqing; Wu Xiangyang

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Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism

机译：葡萄糖摄取和胰岛素敏感信号途径及其机理改善3T3-L1脂肪细胞铬酸铬丙酸盐高葡萄糖和胰岛素抗性

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Previous study has revealed that chromium malate could improve insulin resistance and the regulation of fasting blood glucose in type 2 diabetic rats. This study was designed to investigate the effect of chromium malate on hypoglycemic and improve insulin resistance activities in 3T3-L1 adipocytes with insulin resistance and investigate the acting mechanism. The result indicated that chromium malate exhibited direct hypoglycemic activity in vitro. Compared with the model group, chromium malate could significantly promote the expression levels of GLUT-4, Akt, Irs-1, PPAR, PI3K and p38-MAPK and their mRNA, increase p-AKT/AKT level, AKT and AMPK1 phosphorylation and reduce Irs-1 phosphorylation and p-Irs-1/Irs-1 level in 3T3-L1 adipocytes (p 0.05). Chromium malate is more effective in regulating the proteins and mRNA expressions than those of chromium trichloride and chromium picolinate. Compared to the model group, pretreatment with the specific p38-MAPK inhibitor completely inhibited the GLUT-4 and Irs-1 proteins and mRNA expressions induced by the chromium malate. In conclusion, chromium malate had a beneficial influence on improvement of controlling glucose levels and insulin resistance in 3T3-L1 adipocytes with insulin resistance by regulating proteins productions and genes expressions in glucose uptake and insulin sensitivity signaling pathways.

机译：以往的研究表明，苹果酸铬可以改善胰岛素抵抗和2型糖尿病大鼠中的空腹血糖调节。本研究旨在探讨亚羟酸铬对降血糖和改善胰岛素抵抗的胰岛素抵抗活性的影响，并研究了作用机制。结果表明，亚羟胺在体外表现出直接降血糖活性。与模型组相比，苹果酸铬可以显着促进凝乳-4，AKT，IRS-1，PPAR，PI3K和P38-MAPK及其mRNA的表达水平，增加P-AKT / AKT水平，AKT和AMPK1磷酸化和减少IRS-1磷酸化和P-IRS-1 / IRS-1水平在3T3-L1 adipocytes中（P <0.05）。苹果酸铬更有效地调节蛋白质和mRNA表达，而不是三氯化铬和吡啶钠。与模型组相比，具有特异性P38-MAPK抑制剂的预处理完全抑制了亚羟胺诱导的凝乳-4和IRS-1蛋白和mRNA表达。总之，苹果酸铬对改善控制葡萄糖水平和胰岛素抗性的改善，通过调节蛋白质产量和葡萄糖摄取和胰岛素敏感信号通路中的胰岛素抗性，对胰岛素抗性的控制。

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来源
《RSC Advances》 |2019年第1期|共14页
作者
Feng Weiwei; Liu Yongchao; Fei Fan; Chen Yao; Ding Yangyang; Yan Mengjiao; Feng Yun; Zhao Ting; Mao Guanghua; Yang Liuqing; Wu Xiangyang;
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作者单位

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Med Sci &

Lab Med 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Chem &

Chem Engn 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Chem &

Chem Engn 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

Jiangsu Univ Sch Environm &

Safety Engn Inst Environm Hlth &

Ecol Secur 301 Xuefu Rd Zhenjiang 212013 Jiangsu Peoples R China;

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1. Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism [J] . Feng Weiwei, Liu Yongchao, Fei Fan, RSC Advances . 2019,第1期

机译：葡萄糖摄取和胰岛素敏感信号途径及其机理改善3T3-L1脂肪细胞铬酸铬丙酸盐高葡萄糖和胰岛素抗性
2. Chromium malate alleviates high-glucose and insulin resistance in L6 skeletal muscle cells by regulating glucose uptake and insulin sensitivity signaling pathways [J] . Weiwei Feng, Yangyang Ding, Weijie Zhang, BioMetals: An International Journal on the Role of Metal Ions in Biology, Biochemistry and Medicine . 2018,第5期

机译：通过调节葡萄糖摄取和胰岛素敏感信号通路，亚羟丙酯在L6骨骼肌细胞中减轻了高葡萄糖和胰岛素抗性
3. Chebulagic acid from Terminalia chebula enhances insulin mediated glucose uptake in 3T3-L1 adipocytes via PPAR gamma signaling pathway [J] . Shyni Gangadharan Leela, Kavitha Sasidharan, Indu Sasidharan, BioFactors . 2014,第6期

机译：榄仁茶中的车夫苷酸通过PPARγ信号通路增强3T3-L1脂肪细胞中胰岛素介导的葡萄糖摄取
4. Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes [C] . M.Oda, K.Kusumoto, K.Teruya Annual Meeting of the European Society of Animal Cell Technology . 1999

机译：电解和天然降低的水表现出胰岛素的活性对葡萄糖摄取到肌肉细胞和脂肪细胞
5. The effect of HIV protease inhibitors on insulin binding, triglyceride synthesis, lipolysis, and insulin signaling in 3T3-L1 adipocytes (Immune deficiency). [D] . Cammalleri, Caterina. 2002

机译：HIV蛋白酶抑制剂对3T3-L1脂肪细胞中的胰岛素结合，甘油三酸酯合成，脂解作用和胰岛素信号传导的影响（免疫缺陷）。
6. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes [O] . Hyejin Lee, Hua Li, Minsoo Noh, 2016

机译：补骨脂的Bavachin通过3T3-L1脂肪细胞中的胰岛素信号传导和AMPK活化改善胰岛素依赖性葡萄糖摄取。
7. Bavachin from Psoralea corylifolia Improves Insulin-Dependent Glucose Uptake through Insulin Signaling and AMPK Activation in 3T3-L1 Adipocytes [O] . Hyejin Lee, Hua Li, Minsoo Noh, 2016

机译：psoralea corylifolia的Bavachin通过胰岛素信号和3T3-L1脂肪细胞中的ampK活化改善胰岛素依赖性葡萄糖摄取

Improvement of high-glucose and insulin resistance of chromium malate in 3T3-L1 adipocytes by glucose uptake and insulin sensitivity signaling pathways and its mechanism

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