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Enhanced bactericidal efficacy of polymer stabilized silver nanoparticles in conjugation with different classes of antibiotics

机译：聚合物稳定化的银纳米颗粒与不同种类的抗生素结合可增强杀菌效果

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The paper presents the interaction mechanism of silver nanoparticles (AgNPs) with different antibiotics and the antibacterial efficacy of the formed conjugates. The AgNPs used in this study were synthesized from silver nitrate using sodium borohydride as a reducing agent, in the presence of PVP as a protecting agent. Two antibiotics, amikacin and vancomycin with different modes of action, were used to functionalize the synthesized PVP-capped AgNPs. The formation of antibiotic-AgNPs conjugate was confirmed by UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS) and X-ray diffraction (XRD) and the results suggest the conjugation of both drugs to silver nanoparticle surfaces. FTIR results indicate that intermolecular hydrogen bonding exists between PVP-coated AgNPs and antibiotics. The oxygen atom coordinated with PVP was available for interaction with either amine or amide groups of drugs. Further, the antibacterial efficacy of these PVP-capped AgNPs with selected antibiotics was evaluated against Escherichia coli and Staphylococcus aureus by agar well diffusion test. Synergetic bactericidal activity for antibiotic-AgNPs conjugate was observed against both microbes.
机译：本文介绍了银纳米颗粒（AgNPs）与不同抗生素的相互作用机理以及形成的结合物的抗菌功效。在本研究中使用的AgNPs是在PVP作为保护剂的情况下，用硼氢化钠作为还原剂由硝酸银合成的。具有不同作用方式的两种抗生素阿米卡星和万古霉素可用于功能化合成的PVP封端的AgNP。紫外可见光谱，傅立叶变换红外光谱（FTIR），动态光散射（DLS）和X射线衍射（XRD）证实了抗生素-AgNPs共轭物的形成，结果表明这两种药物都与银纳米颗粒表面结合。 。 FTIR结果表明，PVP包覆的AgNP与抗生素之间存在分子间氢键。与PVP配位的氧原子可用于与药物的胺基或酰胺基相互作用。此外，通过琼脂孔扩散试验评估了这些PVP封端的AgNPs与所选抗生素的抗菌功效，对大肠杆菌和金黄色葡萄球菌。观察到抗生素-AgNPs缀合物对两种微生物的协同杀菌活性。

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