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首页> 外文期刊>The journal of immunology >CD4? Plasmacytoid Dendritic Cells (pDCs) Migrate in Lymph Nodes by CpG Inoculation and Represent a Potent Functional Subset of pDCs
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CD4? Plasmacytoid Dendritic Cells (pDCs) Migrate in Lymph Nodes by CpG Inoculation and Represent a Potent Functional Subset of pDCs

机译：CD4？浆细胞样树突状细胞（pDC）通过CpG接种在淋巴结中迁移，代表pDC的功能强大子集

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We have recently identified two groups of plasmacytoid dendritic cells (pDCs) isolated from murine liver based on the expression of CD4 and other cell surface markers uniquely expressed by pDCs. Herein, we describe the identification of both CD4+ and CD4? pDCs that clearly exist in lymph nodes (LNs), spleen, liver, thymus, bone marrow, and lung. Normally, CD4+ pDCs are enriched in LNs. However, after in vivo systemic injection with bacterial CpG, a larger number of CD4? pDCs are recruited to the LNs and local inoculation by CpG drives CD4? pDCs migrating into local sentinel LNs, suggesting that CD4? pDCs are the main subpopulation migrating to the peripheral LNs. Furthermore, although both freshly isolated CD4+ pDCs and CD4? pDCs appear as an immature plasmacytoid cell and develop into a DC morphology following activation, the two subsets have strikingly different immune features, including differences in the production pattern of cytokines stimulated with CpG and in T cell activation.
机译：我们最近基于CD4的表达和pDC唯一表达的其他细胞表面标志物，鉴定了从鼠肝中分离出的两组浆细胞样树突状细胞（pDC）。在此，我们描述了对CD4 +和CD4？的识别。 pDC明显存在于淋巴结（LN），脾脏，肝脏，胸腺，骨髓和肺中。通常，CD4 + pDC富含LN。但是，在体内全身注射细菌CpG后，会有更多的CD4？ pDC是否被招募到LN并通过CpG驱动器CD4进行本地接种？ pDC迁移到本地前哨LN中，提示CD4？ pDC是迁移到外围LN的主要亚群。此外，尽管新分离的CD4 + pDC和CD4？ pDC表现为未成熟的浆细胞样细胞，并在激活后发展为DC形态，这两个亚群具有显着不同的免疫特征，包括CpG刺激的细胞因子生产模式和T细胞激活的差异。

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