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首页> 外文期刊>The Journal of Experomental Medicine >THE FATE OF TYPHOID BACILLI WHEN INJECTED INTRAVENOUSLY INTO NORMAL RABBITS
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THE FATE OF TYPHOID BACILLI WHEN INJECTED INTRAVENOUSLY INTO NORMAL RABBITS

机译：伤寒杆菌注射伤寒杆菌的命运

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摘要

Typhoid bacilli are agglutinated promptly in the circulating blood of normal rabbits and quickly removed from the blood stream.The clumped bacilli accumulate in the organs and are taken up by assembled polymorphonuclear leucocytes in the liver, spleen, and possibly other organs.The phagocyted clumps of bacilli are digested and destroyed by the phagocytes.Hence, destruction of typhoid bacilli intra vitam is brought about by an entirely different process than is the destruction by serum and whole blood in vitro . While the latter is caused by bacteriolysis, the former results from agglutination and intraphagocytic digestion.Lysis by fresh blood serum is not appreciably affected by spleen or kidney pulp, but it is inhibited by liver pulp. The action of the liver is referable to its biliary constituents, which exert anticomplementary action.Probably in certain examples of typhoid fever in man the typhoid bacilli in the circulating blood being inagglutinable cannot be removed by the organs and hence are not phagocyted and destroyed.The observed disparity between the ready destruction of typhoid bacilli by serum and shed blood and the resistance sometimes offered by the bacilli in the infected body is explained by the essential differences in the destructive processes in operation within and without the body.
机译：伤寒杆菌迅速在正常兔的循环血中凝集并迅速从血流中清除。结块的细菌积聚在器官中，并被肝脏，脾脏以及其他器官中组装的多形核白细胞吸收。细菌被吞噬细胞消化和破坏。因此，伤寒性内伤性杆菌的破坏过程与体外血清和全血的破坏过程完全不同。后者是由溶菌作用引起的，而前者是由凝集作用和吞噬细胞内的消化作用引起的。新鲜血清的裂解不受脾脏或肾髓的影响，但受到肝髓的抑制。肝脏的作用是指其胆汁成分，发挥抗补体作用。在人类伤寒的某些例子中，可能是循环血中不能凝集的伤寒杆菌无法被器官清除，因此不会被吞噬和破坏。观察到的血清和流血立即破坏伤寒杆菌之间的差异，以及细菌在感染体中有时提供的抗性之间的差异，可以通过体内和非体外操作中破坏过程的本质差异来解释。

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