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首页> 外文期刊>The Journal of Experomental Medicine >Antiidiotypes against anti-H-2 monoclonal antibodies. V. In vivo antiidiotype treatment induces idiotype-specific helper T cells.
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Antiidiotypes against anti-H-2 monoclonal antibodies. V. In vivo antiidiotype treatment induces idiotype-specific helper T cells.

机译：抗H-2单克隆抗体的抗独特型。 V.体内抗独特型治疗诱导独特型辅助性T细胞。

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摘要

Mice have been treated in vivo with xenogeneic antiidiotypes prepared against a murine monoclonal anti-H-2Kk antibody, 11-4.1. B cell immune responses have been found to be altered by such treatment as evidenced by a modification in the idiotypic repertoire of the humoral response to H-2 antigens. Transfer of purified T cells into nude mice before anti-idiotype treatment showed that T cells are involved in the induction of idiotope-bearing antibodies by xenogeneic antiidiotype. Studies using bone marrow chimeras indicate that the environment in which either T or B cells mature does not appear to alter VH region genetic control of induction of antiidiotype-induced molecules. By adoptive transfer studies, T cells from antiidiotype-treated mice were found capable of modifying the idiotypic repertoire of B cells subsequently exposed to antigen even when the T cells were obtained from antiidiotype-primed mice of inappropriate allotype. Although it still must be determined whether idiotypic or antiidiotypic T cells are involved in such B cell idiotype regulation, these results indicate that some T cell functions are altered by xenogeneic antiidiotypes prepared against B cell products and suggest that T cell immunity to major histocompatibility complex antigens may also be affected by such reagents.
机译：已经用针对鼠单克隆抗H-2Kk抗体11-4.1制备的异种抗独特型在体内治疗了小鼠。已经发现B细胞免疫应答通过这种治疗而改变，如对H-2抗原的体液应答的独特型库的改变所证明的。在抗独特型治疗之前，将纯化的T细胞转移到裸鼠中表明，T细胞参与了异种抗独特型诱导含独特基因的抗体。使用骨髓嵌合体的研究表明，T细胞或B细胞成熟的环境似乎不会改变VH区抗独特型诱导分子诱导的遗传控制。通过过继转移研究，发现从抗独特型治疗的小鼠的T细胞能够修饰随后暴露于抗原的B细胞的独特型库，即使从不适当同种异型的抗独特型引发小鼠获得T细胞也是如此。尽管仍然必须确定是否独特型或抗独特型T细胞参与这种B细胞独特型调节，但这些结果表明，针对B细胞产物制备的异种抗独特型改变了某些T细胞功能，并暗示了T细胞对主要组织相容性复合抗原的免疫力也可能会受到此类试剂的影响。

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