Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice

F.J. Diaz; K. Wigglesworth; J.J. Eppig

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Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice

机译：卵母细胞是小鼠前壁颗粒细胞向卵丘细胞转变所必需的

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Preantralgranulosacells(PAGCs)differentiateintocumuluscellsfollowingantrumformation.Cumuluscells,butnotPAGCs,arecompetenttoundergoexpansion.ExperimentsreportedheretestedtherespectiverolesofbothoocytesandFSHinthetransitionofpreantralgranulosacellstocumuluscellscompetenttoundergoexpansion.PAGCndash;oocytecomplexeswereculturedwithorwithoutalowdoseofFSH(0.005nbsp;IU/ml)andisolatedPAGCswereculturedwithorwithoutoocytes.Attheendofculture,complexesorisolatedPAGCsweretestedfortheirabilitytoundergocumulusexpansionandupregulateexpansiontranscriptsinresponsetoEGForFSH(0.5nbsp;IU/ml).TheabilitytoundergoexpansioninresponsetoEGFrequiredthepresenceofoocytesbutnotFSHduringthecultureperiod.Likewise,complexesisolatedfromtheovariesofhypogonadalmice,whichlackcirculatinggonadotropins,underwentexpansioninresponsetoEGF,butnotFSH.Incontrast,theabilitytoactivateMAPK3/1andMAPK14andundergoexpansioninresponsetoFSHrequiredpriorexposuretolowdosesofFSH.However,theselowlevels(0.005or0.025nbsp;IUFSH/ml)suppressedexpressionofemSlc38a3/emandemAmh/em,twotranscriptshighlyexpressedincumuluscells,suggestingopposingeffectsofFSHoncumuluscelldifferentiation.Inconclusion,theabilitytoundergoexpansioninresponsetoFSHrequirespriorexposuretoFSHduringdevelopment,whileoocyte-derivedfactorsalonearesufficienttopromotetheabilitytoundergoexpansioninresponsetoEGF.TheseresultshighlightthecrucialroleofoocytesindrivingthedifferentiationofPAGCsintocumuluscellsduringthepreantraltoantralfollicletransition./p/div

机译：Preantralgranulosacells（PAGCs）differentiateintocumuluscellsfollowingantrumformation.Cumuluscells，butnotPAGCs，arecompetenttoundergoexpansion.ExperimentsreportedheretestedtherespectiverolesofbothoocytesandFSHinthetransitionofpreantralgranulosacellstocumuluscellscompetenttoundergoexpansion.PAGCndash; oocytecomplexeswereculturedwithorwithoutalowdoseofFSH（0.005nbsp; IU / ml）的andisolatedPAGCswereculturedwithorwithoutoocytes.Attheendofculture，complexesorisolatedPAGCsweretestedfortheirabilitytoundergocumulusexpansionandupregulateexpansiontranscriptsinresponsetoEGForFSH（0.5nbsp; IU / ml）的.TheabilitytoundergoexpansioninresponsetoEGFrequiredthepresenceofoocytesbutnotFSHduringthecultureperiod.Likewise，complexesisolatedfromtheovariesofhypogonadalmice，whichlackcirculatinggonadotropins，underwentexpansioninresponsetoEGF，butnotFSH与此相反，在低剂量FSH暴露之前，必须先激活FSH才能激活MAPK3 / 1和MAPK14并进行扩展，但是，较低的水平（0.005或0.025纳秒; IUFSH / ml）会抑制sionof Slc38a3 和 AMH ，twotranscriptshighlyexpressedincumuluscells，suggestingopposingeffectsofFSHoncumuluscelldifferentiation.Inconclusion，theabilitytoundergoexpansioninresponsetoFSHrequirespriorexposuretoFSHduringdevelopment，whileoocyte-derivedfactorsalonearesufficienttopromotetheabilitytoundergoexpansioninresponsetoEGF.TheseresultshighlightthecrucialroleofoocytesindrivingthedifferentiationofPAGCsintocumuluscellsduringthepreantraltoantralfollicletransition。 展开▼

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《Developmental biology》 |2007年第1期|共页

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F.J. Diaz; K. Wigglesworth; J.J. Eppig;
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1. Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice [J] . Diaz FJ, Wigglesworth K, Eppig JJ Developmental biology . 2007,第1期

机译：卵母细胞是小鼠前壁颗粒细胞向卵丘细胞转变所必需的

2. The preantral granulosa cell to cumulus cell transition in the mouse ovary: Development of competence to undergo expansion [J] . Diaz FJ, OBrien MJ, Wigglesworth K, Developmental biology . 2006,第1期

机译：小鼠卵巢中前窦颗粒细胞到卵丘细胞的转变：进行扩张的能力的发展

3. The preantral granulosa cell to cumulus cell transition in the mouse ovary: Development of competence to undergo expansion ☆ [J] . F.J. Diaz, M.J. OBrien, K. Wigglesworth, Developmental biology . 2006,第1期

机译：小鼠卵巢前颗粒前细胞向卵丘细胞的转变：进行扩张的能力的发展☆

4. The effect of granulosa cells apoptosis on the cumulus expansion and the developmental competence of bovine oocytes [C] . Weiguo Feng, Zhifang Pan International Conference on Chemical Engineering, Metallurgical Engineering and Metallic Materials . 2014

机译：粒细胞细胞凋亡对牛卵母细胞膨胀和发育能力的影响

5. Study on the growth of oocytes and steroidogenesis of granulosa cells in cattle: Effects of bone morphogenetic protein-4, follicle stimulating hormone and antral follicle count in ovaries on in vitro and in vivo follicular development [D] . 坂口, 謙一郎 2019

机译：牛卵母细胞生长和颗粒细胞类固醇生成的研究：卵巢中骨形态发生蛋白4，卵泡刺激素和胃窦卵泡计数对体内和体外卵泡发育的影响

6. Oocytes are Required for the Preantral Granulosa Cell to Cumulus Cell Transition in Mice [O] . FJ Diaz, K Wigglesworth, JJ Eppig -1

机译：卵母细胞是小鼠前壁颗粒细胞向积云细胞过渡所必需的

7. Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte–cumulus cell complex in mice: genetic evidence for an oocyte–granulosa cell regulatory loop [O] . Su You-Qiang, Wu Xuemei, OBrien Marilyn J., 2004

机译：BMP15和GDF9在小鼠卵母细胞-卵丘细胞复合体的发育和功能中的协同作用：卵母细胞-颗粒细胞调节环的遗传证据

1. 颗粒细胞或卵丘细胞提高小鼠未成熟卵母细胞恢复减数分裂能力的研究 [J] . 李战彪 ,宋振华 ,张攀 . 青岛农业大学学报（自然科学版） . 2010,第001期

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3. 人卵丘细胞与壁颗粒细胞的差异性研究进展 [J] . 高二梦 ,千日成 . 国际生殖健康/计划生育杂志 . 2021,第005期

4. 人卵巢壁层颗粒细胞和卵丘细胞体外分离及原代培养的比较 [J] . 朱洁茹 ,欧建平 ,李涛 . 中国病理生理杂志 . 2020,第012期

5. 卵丘细胞上AIFM2和FDX1的表达及其与小鼠卵母细胞成熟的关系 [J] . 周团萍 ,千日成 ,邵丽 . 生殖医学杂志 . 2017,第006期

6. 卵丘细胞对猪卵母细胞成熟及发育的影响 [C] . 王庆凯 ,赵子墨 ,崔茂盛 . 第六届京津冀一体化畜牧兽医科技创新研讨会暨新思想、新方法、新观点论坛 . 2018

7. BCAS2在小鼠颗粒细胞和卵母细胞中的表达定位及其对颗粒细胞增殖凋亡的影响 [A] . 王彦玲 . 2015

1. 人类卵泡卵丘细胞或/和颗粒细胞的细胞系及其制备方法 [P] . 中国专利： CN112646771A . 2021-04-13

2. 辛酰化Ghrelin在促进牛卵母细胞卵丘细胞复合体雌二醇和孕酮分泌中的应用 [P] . 中国专利： CN111304158B . 2022.01.21

3. Methods Using Cumulus Cells for Identification of Viable Oocytes [P] . 外国专利： US2020049716A1 . 2020-02-13

机译：利用积层细胞鉴定活卵母细胞的方法

4. Genes Differentially Expressed by Cumulus Cells and Assays Using Same to Identify Pregnancy Competent Oocytes [P] . 外国专利： US2014296104A1 . 2014-10-02

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5. Assays for the identification of oocytes with pregnancy competence using genes and their cumulus cells to Sa expression [P] . 外国专利： JP2013510575A . 2013-03-28

机译：利用基因及其卵丘细胞表达Sa来鉴定具有妊娠能力的卵母细胞的方法

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Oocytes are required for the preantral granulosa cell to cumulus cell transition in mice

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