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首页> 外文期刊>Journal of Clinical Microbiology >Clinical and immunological study of percutaneous revaccination in children who originally received smallpox vaccine subcutaneously.
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Clinical and immunological study of percutaneous revaccination in children who originally received smallpox vaccine subcutaneously.

机译：最初皮下接种天花疫苗的儿童经皮再接种的临床和免疫学研究。

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In a large multicenter smallpox vaccination study carried out from 1970 to 1973, it was found that 39% of children who were initially immunized by the subcutaneous route and then challenged percutaneously with a standard vaccination did not have measurable neutralizing antibody upon follow-up. Because of this finding, a percutaneous revaccination study was conducted at the St. Louis study center in 1975 and 1976. There were four study groups, which were composed on the basis of route of primary immunization (subcutaneous or percutaneous) and whether neutralizing antibody was detectable following the original percutaneous challenge immunization. Of 52 children revaccinated, all but four had accelerated reactions. There was no difference in size of lesions or day of maximum erythema among the four study groups. Only 66% of children originally vaccinated subcutaneously who did not have postchallenge neutralizing antibody had measurable neutralizing antibody following revaccination. Transformation studies with vaccinia viral antigen before and after revaccination were performed on lymphocytes from 50 children. There was no appreciable differences in responses either before or after revaccination when the four groups were compared. However, the mean stimulation ratio for the total group increased from 2.4 before revaccination to 4.6 3 weeks later. In primary subcutaneous vaccine recipients without pre-revaccination neutralizing antibody, lymphocyte transformation correlated directly with the neutralizing antibody response.
机译：在1970年至1973年进行的大型多中心天花疫苗接种研究中，发现39％的儿童最初通过皮下途径进行了免疫接种，然后经标准疫苗经皮攻击后在随访中没有可测量的中和抗体。由于这一发现，1975年和1976年在圣路易斯研究中心进行了一次皮肤再接种研究。有四个研究组，它们是根据初次免疫途径（皮下或经皮）以及是否使用中和抗体组成的。最初的经皮激发免疫后可检测到。在52名接受过疫苗接种的儿童中，除了4名儿童之外，其他所有儿童的反应都加快了。在四个研究组中，病变的大小或最大红斑日均无差异。最初未进行攻击后中和抗体的皮下接种儿童中，只有66％的儿童在重新接种后具有可测量的中和抗体。分别对50名儿童的淋巴细胞进行了疫苗接种前后免疫牛痘病毒抗原的转化研究。比较这四组时，在疫苗接种之前或之后的反应没有明显差异。但是，整个组的平均刺激率从接种前的2.4增加到3周后的4.6。在未接种疫苗前中和抗体的皮下一级疫苗接种者中，淋巴细胞转化与中和抗体反应直接相关。

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