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首页> 外文期刊>Journal of animal science >The effects of dietary supplementation with hyodeoxycholic acid on the differentiation and function of enteroendocrine cells and the serum biochemical indices in weaned piglets
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The effects of dietary supplementation with hyodeoxycholic acid on the differentiation and function of enteroendocrine cells and the serum biochemical indices in weaned piglets

机译：日粮添加猪去氧胆酸对断奶仔猪肠内分泌细胞分化和功能及血清生化指标的影响。

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Bile acid, a cholesterol metabolite, promotes gastrointestinal tract digestion and absorption of cholesterol, lipids, and fat-soluble vitamins. It is a signaling regulatory molecule that influences a variety of endocrinal and metabolic activities. This study investigated the effects of hyodeoxycholic acid (HDCA) as a dietary supplement on endocrine cell differentiation and function and weaned piglet serum biochemical indices. Sixteen piglets [Duroc × (Landrace × Yorkshire)] were individually housed and weaned at 21 d of age (BW of 6.14 ± 0.22 kg). Uniform weight animals were randomly assigned to 1 of 2 treatments (8 replicate pens per treatment and 1 piglet per pen). The treatments were 1) base diet (control) and 2) base diet supplemented with 2 g/kg of HDCA. Control and HDCA piglet numbers of chromogranin A (CgA)-positive cells per crypt did not differ. HDCA CgA-positive cells numbers decreased (P 0.05) in the jejunal villi showed a tendency to decrease (P 0.10) in the ileal villi and showed tendency toward an increase (P 0.10) in the duodenal villi compared with the controls. The HDCA diet led to a decline in glucagon-like peptide 2 (P 0.01) concentrations, but did not affect plasma glucagon-like peptide 1. HDCA supplementation increased (P 0.05) the mRNA expression of jejunal Insm1, Sst, PG, and Gast, but decreased (P 0.05) duodenal expression of Insm1, jejunal Pdx1, and ileal NeuroD1. HDCA elevated globulin and immunoglobulin A (P 0.05) serum concentrations and decreased the albumin/globulin ratio (P 0.05). Total protein and immunoglobulin G serum levels tended to increase compared with the control group. These results indicate that dietary HDCA at 2 g/kg may regulate enteroendocrine cell differentiation and play a role in increasing weaned piglet humoral immunity.
机译：胆汁酸是胆固醇的代谢产物，可促进胃肠道对胆固醇，脂质和脂溶性维生素的消化和吸收。它是一种信号调节分子，可影响多种内分泌和代谢活动。这项研究调查了猪去氧胆酸（HDCA）作为膳食补充剂对内分泌细胞分化和功能以及断奶仔猪血清生化指标的影响。分别饲养十六只仔猪[Duroc×（Landrace×Yorkshire）]，并在21 d龄时断奶（体重6.14±0.22 kg）。将体重均匀的动物随机分配至2种处理方法中的一种（每处理8支重复笔，每支猪1头仔猪）。治疗方法是1）基础饮食（对照）和2）补充2 g / kg HDCA的基础饮食。每个隐窝嗜铬粒蛋白A（CgA）阳性细胞的对照和HDCA仔猪数量没有差异。与对照组相比，空肠绒毛中HDCA CgA阳性细胞数量减少（P <0.05），回肠绒毛中有减少趋势（P <0.10），十二指肠绒毛中HDCA CgA阳性细胞数量有增加趋势（P <0.10）。 HDCA饮食导致胰高血糖素样肽2的浓度降低（P <0.01），但不影响血浆胰高血糖素样肽1的浓度。HDCA的添加增加了（P <0.05）空肠Insm1，Sst，PG，和Gast，但Insm1，空肠Pdx1和回肠NeuroD1的十二指肠表达降低（P <0.05）。 HDCA升高球蛋白和免疫球蛋白A的血清浓度（P <0.05），并降低白蛋白/球蛋白比（P <0.05）。与对照组相比，总蛋白和免疫球蛋白G血清水平趋于增加。这些结果表明，日粮HDCA 2 g / kg可能调节肠内分泌细胞分化，并在增加断奶仔猪体液免疫中发挥作用。

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