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首页> 外文期刊>Journal of Clinical Microbiology >Rubella virus hemagglutination with human and animal erythrocytes: effect of age and trypsinization.
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Rubella virus hemagglutination with human and animal erythrocytes: effect of age and trypsinization.

机译：风疹病毒与人和动物红细胞的血凝反应：年龄和胰蛋白酶消化的影响。

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摘要

Sensitivity to rubella virus hemagglutination differs considerably with newborn as opposed to adult erythrocytes (RBC) in several animal species. In humans, cord RBC are 16 times more sensitive to hemagglutination, whereas hemagglutination titers with newborn RBC are 6 to 16 times higher in chickens, mice, and rabbits. This higher sensitivity is, however, short-lived, and adult RBC values are observed 7 days after birth in mice. Trypsinization has no effect on newborn RBC, but increases sensitivity of adult RBC to that of neonatal RBC and tends to diminish differences among individuals. On the other hand, trypsinization does not further enhance the very high sensitivity of pigeon, duck, and goose RBC or the low sensitivity of both newborn and adult guinea pig RBC. Human cord RBC proved suitable for use in hemagglutination-inhibition tests, since they gave titers comparable to those obtained with other types of RBC and offered some advantages: by comparison with animal RBC, they did not require adsorption to remove nonspecific agglutinins; by comparison with adult human RBC, they did not need trypsinization.
机译：在一些动物中，新生儿对风疹病毒血凝的敏感性与成年红细胞（RBC）相反。在人类中，脐带RBC对血凝敏感性高16倍，而在鸡，小鼠和兔子中，新生RBC的血凝滴度高6至16倍。然而，这种较高的敏感性是短暂的，并且在小鼠出生后7天观察到成年RBC值。胰蛋白酶消化对新生儿RBC没有影响，但是增加了成人RBC对新生儿RBC的敏感性，并倾向于减少个体之间的差异。另一方面，胰蛋白酶消化不能进一步提高鸽子，鸭和鹅RBC的非常高的敏感性或新生和成年豚鼠RBC的低敏感性。人脐带红细胞被证明适合用于血凝抑制试验，因为它们的滴度与其他类型的红细胞相当，并且具有一些优势：与动物红细胞相比，它们不需要吸附来去除非特异性凝集素;与成人RBC相比，他们不需要胰蛋白酶消化。

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