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首页> 外文期刊>Journal of Clinical Microbiology >Immunoglobulin G and immunoglobulin M antibody responses of patients with malignancies to the O antigens of bacteria causing bacteremia.
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Immunoglobulin G and immunoglobulin M antibody responses of patients with malignancies to the O antigens of bacteria causing bacteremia.

机译：恶性肿瘤患者对引起菌血症的细菌的O抗原的免疫球蛋白G和免疫球蛋白M抗体反应。

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摘要

Malignancy may be associated with impairment of the immune system. In children with acute leukemia, an impaired immunoglobulin M (IgM) antibody response to poliovirus was documented previously. It was of interest, therefore, to determine the immunoclass of antibodies produced against the O antigens of bacteria causing bacteremia in patients with leukemia and other malignancies. For control purposes, parallel studies were carried out in patients without maligancies but with infections caused by gram-negative bacteria. The patients with malignancies were adults, and those without malignancies were children. The serum specimens were selected from patients mounting an antibody response. IgG and IgM antibodies were identified by mercaptoethanol reduction and chromatography. Antibody titers against the O antigens of enteric bacteria were determined by the hemagglutination procedure. Antibodies of both IgM and IgG immunoclasses were produced by all but 1 of 16 patients with leukemia and by all but 1 of 12 subjects with other malignancies. Thus, a specific IgM immune deficiency in adult patients with leukemia or other malignancies complicated by bacteremia was not present; however, the magnitude of the antibody response of the patient with leukemia was less than that of the subjets with other maligancies, with the median antibody titers of the former being 320 and those of the latter being 2,560.
机译：恶性肿瘤可能与免疫系统受损有关。在急性白血病患儿中，先前已证明对脊髓灰质炎病毒的免疫球蛋白M（IgM）抗体应答受损。因此，感兴趣的是确定针对白血病和其他恶性肿瘤患者中引起菌血症的细菌的O抗原产生的抗体的免疫类别。为了控制目的，在没有恶意但有革兰氏阴性细菌感染的患者中进行了平行研究。恶性肿瘤患者为成年人，无恶性肿瘤的患者为儿童。血清标本选自发生抗体反应的患者。 IgG和IgM抗体通过巯基乙醇还原和色谱法鉴定。通过血凝过程确定针对肠细菌的O抗原的抗体效价。 IgM和IgG免疫类别的抗体均由16名白血病患者中的1名除外和其他恶性肿瘤患者中的12名中的除1名之外的所有患者产生。因此，在成人白血病或其他伴有菌血症的恶性肿瘤患者中，不存在特异性的IgM免疫缺陷。然而，白血病患者的抗体应答幅度小于其他伴有白血病的子射流，前者的中位抗体效价为320，后者的中位抗体效价为2,560。

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