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首页> 外文期刊>Journal of Clinical Microbiology >Pseudomonas aeruginosa enzyme profiling: predictor of potential invasiveness and use as an epidemiological tool.
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Pseudomonas aeruginosa enzyme profiling: predictor of potential invasiveness and use as an epidemiological tool.

机译：铜绿假单胞菌酶图谱：潜在侵袭性的预测因子并用作流行病学工具。

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摘要

The enzymatic potential of 54 clinical and 22 environmental isolates of Pseudomonas aeruginosa from soil and water were evaluated by substrate plate assays. Clinical isolates produced substantial levels of 9 of the 11 enzymes assayed, whereas strains recovered from soil or water were relatively inert enzymatically. Elastase, deoxyribonuclease, and elevated protease activities were associated preferentially with clinical isolates of systemic origin; these activities were found twice as frequently in clinical isolates as in strains derived from sputum or the urogenital tract. Our data suggest that these factors may play an important role in the dissemination of P. aeruginosa from local or superficial sites. A comparison of the enzyme profiles of the environmental and clinical isolates indicated that colonization or infection by environmental strains of P. aeruginosa is a rare event and that environmental and clinical strains comprise separate biovars. Epidemiologically, enzyme profiles permitted the fingerprinting and differentiation of clinical strains from various sources.
机译：通过底物平板测定法评估了54种临床和22种环境菌株从土壤和水中的铜绿假单胞菌的酶促潜力。临床分离株在检测的11种酶中产生了9种，而从土壤或水中回收的菌株在酶学上相对呈惰性。弹性蛋白酶，脱氧核糖核酸酶和升高的蛋白酶活性优先与系统起源的临床分离株相关。在临床分离物中发现这些活性的频率是从痰液或泌尿生殖道中分离出的菌株的两倍。我们的数据表明，这些因素在铜绿假单胞菌从局部或浅表部位的传播中可能起重要作用。对环境和临床分离株的酶谱的比较表明，铜绿假单胞菌的环境菌株定植或感染是罕见的事件，环境和临床菌株包括单独的生物变种。在流行病学上，酶谱允许对来自各种来源的临床菌株进行指纹鉴定和区分。

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