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首页> 外文期刊>Journal of Clinical Microbiology >Immunoglobulin level in donor blood reactive for antibodies to human immunodeficiency virus.
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Immunoglobulin level in donor blood reactive for antibodies to human immunodeficiency virus.

机译：供血中对人免疫缺陷病毒抗体有反应性的免疫球蛋白水平。

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Blood samples from 98 asymptomatic volunteer blood donors, including 55 that were reactive for antibodies to human immunodeficiency virus (HIV) in Western blot (WB) assay, were tested for levels of immunoglobulin G (IgG), IgM, and titer of antibodies to HIV, cytomegalovirus, and herpes simplex virus. Levels of IgG were significantly elevated (P less than or equal to 0.001) in donors with specific anti-HIV reactivity. A total of 69% of donors with anti-HIV had IgG levels of greater than or equal to 12 mg/ml, and 44% had IgG levels of greater than or equal to 14.5 mg/ml. Levels of IgM were not significantly different among WB-reactive and nonreactive donors. The titer of anti-HIV was significantly (P less than 0.02) correlated with IgG levels among donors reactive in the WB assay. Elevation of IgG, however, was not significantly associated with the presence of anticytomegalovirus or anti-herpes simplex virus antibodies. The data show that elevation of IgG may represent an early manifestation of HIV infection before the development of clinical symptoms of acquired immunodeficiency syndrome.
机译：测试了98名无症状自愿献血者的血液样本，其中包括55种在Western blot（WB）分析中对人免疫缺陷病毒（HIV）抗体具有反应性的血液，测试了免疫球蛋白G（IgG），IgM的水平以及针对HIV的抗体滴度，巨细胞病毒和单纯疱疹病毒。具有特定抗HIV反应性的供体的IgG水平显着升高（P小于或等于0.001）。共有69％的抗HIV供者的IgG水平大于或等于12 mg / ml，44％的IgG水平大于或等于14.5 mg / ml。在WB反应性和非反应性供体之间，IgM水平无显着差异。在WB试验中有反应的供体中，抗HIV的效价与IgG水平显着相关（P小于0.02）。然而，IgG的升高与抗巨细胞病毒或抗单纯疱疹病毒抗体的存在没有显着相关。数据表明，在获得性免疫缺陷综合症的临床症状出现之前，IgG升高可能代表了HIV感染的早期表现。

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