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首页> 外文期刊>Journal of Clinical Microbiology >Collagen binding in clinical isolates of Staphylococcus aureus.
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Collagen binding in clinical isolates of Staphylococcus aureus.

机译：金黄色葡萄球菌临床分离物中的胶原蛋白结合。

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Collagen binding was examined in 90 strains of Staphylococcus aureus derived from patient samples. Slightly under one-half (39 of 90) of the S. aureus strains bound collagen. Collagen binding in S. aureus did not correlate with either immunoglobulin G or fibronectin binding by these organisms. Chi-square analysis of isolates obtained from patients with complicated bacteremia (bacteremia associated with deep tissue infection) compared with isolates from patients with uncomplicated bacteremia (bacteremia without other infection) showed that the former strains were significantly more likely to have collagen-binding ability. Subcloning of primary isolates from patients with bacteremia showed that all clones from individual patients were either all positive for collagen binding or all negative, suggesting a common clonal origin for this characteristic. The ability to bind collagen could not be induced in strains lacking collagen affinity by repeated subculture in media supplemented with collagen.
机译：在源自患者样品的90株金黄色葡萄球菌中检测了胶原蛋白的结合。在金黄色葡萄球菌菌株的一半以下（占90个中的39个）结合了胶原蛋白。金黄色葡萄球菌中的胶原蛋白结合与这些生物体的免疫球蛋白G或纤连蛋白结合均不相关。从复杂菌血症（与深部组织感染相关的菌血症）患者获得的分离株与未发生菌血症（无其他感染的菌血症）患者的分离株进行卡方分析表明，前者菌株具有胶原结合能力的可能性更高。来自菌血症患者的初级分离株的亚克隆表明，来自单个患者的所有克隆对胶原蛋白结合都是阳性或全部阴性，表明该特征的共同克隆起源。在缺乏胶原蛋白亲和力的菌株中，不能通过在补充胶原蛋白的培养基中反复传代培养来诱导结合胶原蛋白的能力。

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