Sequences of Pneumocystis carinii f. sp. hominis strains associated with recurrent pneumonia vary at multiple loci.

S P Keely; J R Stringer

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Sequences of Pneumocystis carinii f. sp. hominis strains associated with recurrent pneumonia vary at multiple loci.

机译：卡氏肺孢子虫的序列f。 sp。与复发性肺炎相关的人型菌株在多个位点处变化。

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The sequences of the internal transcribed spacer (ITS) of Pneumocystis carinii f. sp. hominis strains from 7 of 15 AIDS patients were found to vary during discrete episodes of P. carinii pneumonia. Changes in the ITS sequence correlated with changes in the mitochondrial large-subunit rRNA sequence. The coincidence of changes in the sequences of the ITS, which is located in the nucleus, with changes in a mitochondrial gene excludes mutation as the cause of the genetic differences between P. carinii f. sp. hominis strains isolated during different episodes of P. carinii pneumonia and supports the hypothesis that recurrent P. carinii pneumonia is caused by reinfection rather than by reactivation of latent organisms. Thus, limiting the exposure of immunocompromised patients to P. carinii f. sp. hominis should help prevent P. carinii pneumonia.

机译：卡氏肺孢子虫内部转录间隔区（ITS）的序列。 sp。发现15例AIDS患者中有7例的人型菌株在卡氏疟原虫肺炎的离散发作中有所不同。 ITS序列的变化与线粒体大亚基rRNA序列的变化相关。位于核内的ITS序列的变化与线粒体基因变化的重合，排除了突变，因为突变是导致卡氏疟原虫之间遗传差异的原因。 sp。在卡氏疟原虫肺炎的不同发作期间分离出的人型菌株，支持以下假说：卡氏疟原虫复发是由再感染而不是由潜伏生物的再活化引起的。因此，限制了免疫受损患者对卡氏疟原虫的暴露。 sp。人类应该帮助预防卡氏疟原虫肺炎。

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《Journal of Clinical Microbiology》 |1997年第11期|共3页
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S P Keely; J R Stringer;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora. [J] . A E Wakefield Journal of Clinical Microbiology . 1996,第7期

机译：与卡氏肺孢子虫相同的DNA序列。 sp。卡林氏和卡氏肺孢子虫f。 sp。空气孢子样本中的人类。
2. Genetic analysis of multiple loci suggests that mutations in the Pneumocystis carinii f. sp. hominis dihydropteroate synthase gene arose independently in multiple strains. [J] . Ma L, Kovacs JA Antimicrobial agents and chemotherapy. . 2001,第11期

机译：多个基因座的遗传分析表明，卡氏肺孢子虫突变。 sp。人双氢蝶呤合酶基因在多个菌株中独立出现。
3. Genetic analysis of multiple loci suggests that mutations in the Pneumocystis carinii f. sp. hominis dihydropteroate synthase gene arose independently in multiple strains. [J] . Ma L, Kovacs JA Antimicrobial agents and chemotherapy. . 2001,第11期

机译：多个基因座的遗传分析表明，卡氏肺孢子虫突变。 sp。人双氢蝶呤合酶基因在多个菌株中独立出现。
4. Genetic variation in Fusarium oxysporum f. sp. conglutinans strains causing fusarium-wilt of canola in Western Canada [C] . Jeremy Klassen, CHEN Yu, Ralph Lange, Proceedings of the 12th International Rapeseed Congress: Sustainable Development in Cruciferous Oilseed Crops Production . 2007

机译：尖孢镰刀菌的遗传变异sp。引起加拿大西部双低油菜枯萎病的粘连菌株
5. Development of an improved rat model of Pneumocystis carinii pneumonia and investigations of novel chemotherapeutic agents. [D] . Williams-Eckert, Deborah Elizabeth. 1994

机译：改进的卡氏肺孢子虫肺炎大鼠模型的开发和新型化学治疗剂的研究。
6. Sequences of Pneumocystis carinii f. sp. hominis strains associated with recurrent pneumonia vary at multiple loci. [O] . S P Keely, J R Stringer 1997

机译：卡氏肺孢子虫的序列f。 sp。与复发性肺炎相关的人型菌株在多个位点处变化。
7. DNA sequences identical to Pneumocystis carinii f. sp. carinii and Pneumocystis carinii f. sp. hominis in samples of air spora [O] . A E Wakefield 1996

机译：DNA序列与肺肺肺肺骨杆菌序列相同。 sp。 Carinii和Pneumocystis carinii f。 sp。 Hominis在空气Spora样本中

Sequences of Pneumocystis carinii f. sp. hominis strains associated with recurrent pneumonia vary at multiple loci.

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