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首页> 外文期刊>Journal of Clinical Microbiology >Development of serum antibodies of the immunoglobulin G class and subclasses against the capsular polysaccharide of Haemophilus influenzae type b in children and adults with invasive infections.
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Development of serum antibodies of the immunoglobulin G class and subclasses against the capsular polysaccharide of Haemophilus influenzae type b in children and adults with invasive infections.

机译：在患有侵袭性感染的儿童和成人中，针对b型流感嗜血杆菌荚膜多糖的免疫球蛋白G类和亚类血清抗体的开发。

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摘要

The development of total immunoglobulin G (IgG) antibodies and antibodies of the four IgG subclasses in serum against Haemophilus influenzae type b capsular polysaccharide (CPS) was studied in 24 children and 11 adults with invasive Haemophilus influenzae type b infections, by using an enzyme-linked immunosorbent assay. None of the 8 children aged 10 months or younger had increases in the IgG class or in any of the IgG subclasses. In contrast, 14 of 16 children between 10 months and 6 years of age and 10 of 11 adults had significant increases in total IgG, IgG1, or IgG2 antibodies in various combinations, but none of them had increases in IgG3 or IgG4 antibodies. The increases in IgG1 and IgG2 antibodies in the children were of similar magnitudes. Of 11 adult patients, 9 had significant increases in IgG2 antibodies, while only 4 had increases in IgG1 antibodies. In conclusion, this study shows that children younger than approximately 1 year have no IgG response to H. influenzae type b CPS, while individuals above this age have a mixed IgG1 and IgG2 response.
机译：通过使用以下酶，在24例儿童和11例侵袭性B型流感嗜血杆菌感染中研究了总免疫球蛋白G（IgG）抗体和血清中针对B型流感嗜血杆菌荚膜多糖（CPS）的四种IgG亚类抗体的发展。连锁免疫吸附测定。年龄在10个月以下的8个孩子中，没有IgG类或任何IgG亚类的增加。相比之下，年龄在10个月至6岁之间的16名儿童中有14名，以及11名成年人中的10名成年人在各种组合中的总IgG，IgG1或IgG2抗体均显着增加，但IgG3或IgG4抗体均无增加。儿童中IgG1和IgG2抗体的增加幅度相似。在11名成年患者中，有9名IgG2抗体显着增加，而只有4名IgG1抗体增加。总之，这项研究表明，大约1岁以下的儿童对b型流感嗜血杆菌CPS没有IgG应答，而这个年龄以上的儿童则有IgG1和IgG2混合应答。

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