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首页> 外文期刊>Journal of Clinical Microbiology >Cross-sectional study of reverse transcriptase-inhibiting antibody as a marker of acquired immune deficiency syndrome.
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Cross-sectional study of reverse transcriptase-inhibiting antibody as a marker of acquired immune deficiency syndrome.

机译：逆转录酶抑制抗体作为获得性免疫缺陷综合症标志物的横断面研究。

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A cross-sectional study of 128 individuals infected with human immunodeficiency virus type 1 (HIV-1) was conducted to determine the correlation of reverse transcriptase-inhibiting (RTI) antibody to clinical disease. Thirty-two individuals were studied in each of four clinical groups: asymptomatic individuals, those with persistent generalized lymphadenopathy, those with acquired immune deficiency syndrome (AIDS)-related complex, and those with AIDS. Our study showed that 78% of asymptomatic individuals, 53% of those with persistent generalized lymphadenopathy, 50% of those with AIDS-related complex, and only 25% of those with AIDS have RTI antibody. Concurrent measurement of measles antibody level was used as an indicator of the immune status of these individuals. Measles antibody did not decline in persons with clinical disease, but asymptomatic individuals had lower antibody titers, possibly due to hypergammaglobulinemia associated with advanced HIV infection. These results indicate that more HIV-infected asymptomatic individuals than symptomatic individuals have RTI antibody. This suggests either that the RTI antibody level decreases with the progression of disease in HIV infection or that symptomatic individuals do not produce RTI antibody. The presence or absence of RTI antibody can thus be used as a marker of advanced disease.
机译：进行了一项针对128例感染1型人类免疫缺陷病毒（HIV-1）的个体的横断面研究，以确定逆转录酶抑制（RTI）抗体与临床疾病的相关性。在四个临床组的每一个中研究了32个个体：无症状个体，患有持续性全身性淋巴结病的个体，患有获得性免疫缺陷综合症（AIDS）相关综合症的个体以及患有AIDS的个体。我们的研究表明，无症状的人中有78％，持续的全身性淋巴结病患者中有53％，艾滋病相关的复合体中有50％，艾滋病患者中只有25％具有RTI抗体。同时检测麻疹抗体水平被用作这些个体免疫状态的指标。麻疹抗体在临床疾病患者中并未下降，但无症状者的抗体滴度较低，可能是由于与晚期HIV感染相关的高球蛋白血症。这些结果表明具有RTI抗体的HIV感染无症状个体多于有症状个体。这表明RTI抗体水平随HIV感染中疾病的进展而降低，或者有症状的个体不产生RTI抗体。因此，RTI抗体的存在或不存在可以用作晚期疾病的标志。

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