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首页> 外文期刊>Journal of Clinical Microbiology >Oligonucleotide (GTG)5 as a marker for Mycobacterium tuberculosis strain identification.
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Oligonucleotide (GTG)5 as a marker for Mycobacterium tuberculosis strain identification.

机译：寡核苷酸（GTG）5作为结核分枝杆菌菌株鉴定的标记。

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Culture of Mycobacterium tuberculosis provides no information on the identity of a strain or the distribution of such a strain in the community. Strain identification of M. tuberculosis can help to address important epidemiological questions, e.g., the origin of an infection in a patient's household or community, whether reactivation of infection is endogenous or exogenous in origin, and the spread and early detection of organisms with acquired antibiotic resistance. To research this problem, strain identification must be reliable and accurate. Although genetic identification techniques already exist, it is valuable to have genetic identification techniques based on a number of genetic markers to improve the accurate identification of M. tuberculosis strains. We show that oligonucleotide (GTG)5 can be successfully applied to the identification of M. tuberculosis strains. This technique may be particularly useful in cases in which M. tuberculosis strains have few or no insertion elements (e.g., IS6110) or in identifying other strains of mycobacteria when informative probes are lacking.
机译：结核分枝杆菌的培养物未提供有关菌株身份或该菌株在社区中的分布的信息。结核分枝杆菌的菌株鉴定可以帮助解决重要的流行病学问题，例如，患者家庭或社区中感染的起源，感染的恢复是内源还是外源的，以及使用获得性抗生素的生物的传播和早期发现抵抗性。要研究此问题，应变识别必须可靠且准确。尽管遗传鉴定技术已经存在，但是具有基于多种遗传标记的遗传鉴定技术对提高结核分枝杆菌菌株的准确鉴定非常有价值。我们表明，寡核苷酸（GTG）5可以成功地应用于结核分枝杆菌菌株的鉴定。在结核分枝杆菌菌株几乎没有或没有插入元件的情况下（例如IS6110），或者在缺乏信息探针的情况下鉴定其他分枝杆菌菌株时，该技术可能特别有用。

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