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首页> 外文期刊>Journal of Clinical Microbiology >Examination of feces and serum for diagnosis of infant botulism in 336 patients.
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Examination of feces and serum for diagnosis of infant botulism in 336 patients.

机译：检查粪便和血清以诊断336例婴儿肉毒杆菌中毒。

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In the 12-year period 1975 to 1987, feces from 336 infants were examined for botulinal neurotoxin and Clostridium botulinum. All the infants had illnesses which prompted their physicians to consider infant botulism in the diagnosis. Stool specimens from 113 of the infants yielded organisms that produced botulinal neurotoxins assumed to be responsible for the illness. The types of botulinal toxin in the confirmed cases were distributed as follows: 38 A, 69 B, 2 atypical B, 1 E, 1 F, 1 A + B, and 1 B + F. The type A and B toxins in a single infant were produced by two different strains of organism, and the type B and F toxins in another infant were produced by a single strain. The physiological characteristics of all the isolated toxigenic organisms except two were consistent with those of group I (proteolytic) C. botulinum. The toxigenic isolate from the infant with type E botulism was identified as C. butyricum, and that from the infant with type F botulism was identified as C. barati. Toxin of the same type as produced by the isolated organisms was identified in feces of 98 of 111 culture-positive infants. Botulinal toxin was identified in the serum of 9 of 67 culture-positive infants (8 of 22 infants with type A organisms; 1 of 43 infants with type B organisms; neither of 2 infants with A + B or atypical type B organisms). Botulinal toxin was not detected in feces (206 infants) or in serum (114 infants) of the culture-negative infants. The culture-positive infants had clinical features and a course of illness consistent with those of infant botulism. Most of the culture-negative infants probably had illnesses other than botulism, but specimens might have been obtained late in some infants' illnesses, when the organism had disappeared.
机译：在1975年至1987年的12年中，检查了336名婴儿的粪便中的肉毒神经毒素和肉毒梭菌。所有婴儿均患有疾病，促使其医师在诊断中考虑婴儿肉毒中毒。来自113名婴儿的粪便标本产生了产生肉毒杆菌神经毒素的生物体，据认为是造成这种疾病的原因。在确诊病例中，肉毒毒素的类型分布如下：38 A，69 B，2个非典型B，1 E，1 F，1 A + B和1 B +F。婴儿是由两种不同的生物体产生的，而另一名婴儿的B型和F型毒素是由一种菌株产生的。除两个外，所有分离的产毒生物的生理学特征均与I组（蛋白水解）肉毒梭菌一致。来自E型肉毒中毒婴儿的产毒分离株被鉴定为丁酸梭菌，而来自F型肉毒中毒婴儿的毒素分离物被鉴定为C. barati。在111名培养阳性婴儿的98名粪便中鉴定出与分离的生物体产生的毒素类型相同的毒素。在67名培养阳性婴儿中的9名血清中鉴定出肉毒杆菌毒素（22名A型生物婴儿中的8名; 43名B型生物婴儿中的1名; A + B或非典型B型生物的2名婴儿中均没有）。在培养阴性婴儿的粪便（206例婴儿）或血清（114例婴儿）中未检测到肉毒毒素。培养阳性的婴儿具有与婴儿肉毒杆菌中毒相一致的临床特征和病程。大多数培养阴性的婴儿可能除了肉毒杆菌中毒以外，还患有其他疾病，但是在某些婴儿的疾病中，这种微生物消失了，可能是在较晚的时候获得了标本。

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