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首页> 外文期刊>Journal of Clinical Microbiology >Prevalence of gram-negative bacilli in nares and on hands of pharmacy personnel: lack of effect of occupational exposure to antibiotics.
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Prevalence of gram-negative bacilli in nares and on hands of pharmacy personnel: lack of effect of occupational exposure to antibiotics.

机译：鼻孔和药房人员中革兰阴性杆菌的流行：缺乏职业性接触抗生素的影响。

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摘要

Exposure to antibiotics alters host flora and facilitates colonization by gram-negative bacilli (GNB). This may be important among pharmacy personnel, who have frequent contact with antibiotics and who have sometimes been suspected of inadvertently introducing GNB into parenteral solutions during admixture. We evaluated the risk of colonization by GNB, especially by tribe Klebsielleae (TK) which can proliferate in intravenous fluids, by culturing the hands and nares of 98 pharmacy personnel and 56 control subjects. Four culture surveys of pharmacy personnel yielded mean isolation rates of 79 and 52% for GNB and TK, respectively, from hands and 12 and 6.7% for GNB and TK, respectively, from nares; these rates did not differ significantly from those for control subjects (P greater than 0.1). The frequency with which pharmacy personnel performed antibiotic admixture did not significantly affect the rate of isolation of GNB or TK (P greater than 0.2). No multiresistant strains were isolated, and susceptibility patterns were similar for GNB species from pharmacy personnel and controls. These data indicate that occupational exposure of pharmacy personnel to antibiotics is not of sufficient magnitude to increase rates of nasal colonization or hand contamination with GNB.
机译：暴露于抗生素会改变宿主菌群，并促进革兰氏阴性杆菌（GNB）定殖。这对于经常与抗生素接触并且有时被怀疑在混合过程中无意中将GNB引入肠胃外溶液的药房人员来说可能很重要。我们通过培养98名药房人员和56名对照受试者的手和鼻孔，评估了GNB尤其是克雷伯氏菌（TK）可以在静脉输液中增殖的定植风险。对药房人员进行的四次文化调查得出，从双手中分离出GNB和TK的平均隔离率分别为79％和52％，从鼻孔分离出GNB和TK的平均分离率分别为12％和6.7％。这些比率与对照组没有显着差异（P大于0.1）。药房人员进行抗生素混合的频率不会显着影响GNB或TK的分离率（P大于0.2）。没有分离出多药耐药菌株，并且药房人员和对照组对GNB的敏感性模式相似。这些数据表明，药房人员的职业性接触抗生素的程度不足以提高鼻定植率或GNB造成手部污染。

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