Discrimination between Clinically Relevant and NonrelevantAcanthamoeba Strains Isolated from Contact Lens- Wearing Keratitis Patients in Austria

J. Walochnik; E.-M. Haller-Schober; H. K?lli; O. Picher; A. Obwaller; H. Asp?ck

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Discrimination between Clinically Relevant and NonrelevantAcanthamoeba Strains Isolated from Contact Lens- Wearing Keratitis Patients in Austria

机译：奥地利戴隐形眼镜的角膜炎患者分离的临床相关和不相关棘阿米巴菌株的区别

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Eighteen cases of Acanthamoeba-associated keratitis among contact lens wearers seen at the Department of Ophthalmology, Karl-Franzens-University, Graz, Austria, between 1996 and 1999 are reviewed. The amoebae were proven to be the causative agents in three patients. The aim of our study was to discriminate between clinically relevant and nonrelevant isolates and to assess the relatedness of the isolates to published strains. Altogether, 20 strains of free-living amoebae, including 15Acanthamoeba strains, 3 Vahlkampfiastrains, and 2 Hartmannella strains, were isolated from clinical specimens. The virulent Acanthamoebastrains were identified as A. polyphaga and two strains ofA. hatchetti. To our knowledge this is the first determination of keratitis-causing Acanthamoebastrains in Austria. Clinically relevant isolates differed markedly from nonrelevant isolates with respect to their physiological properties. 18S ribosomal DNA sequence types were determined for the three physiologically most-divergent strains including one of the keratitis-causing strains. This highly virulent strain exhibited sequence type T6, a sequence type not previously associated with keratitis. Sequence data indicate thatAcanthamoeba strains causing keratitis as well as nonpathogenic strains of Acanthamoeba in Austria are most closely related to published strains from other parts of the world. Moreover, the results of our study support the assumption that pathogenicity in Acanthamoeba is a distinct capability of certain strains and not dependent on appropriate conditions for the establishment of an infection.

机译：回顾了1996年至1999年间在奥地利格拉茨的卡尔·弗朗森斯大学眼科学系发现的18例隐形眼镜佩戴者中的 Acanthamoeba 相关性角膜炎。变形虫被证明是三例患者的病原体。我们研究的目的是区分临床相关和不相关的分离株，并评估分离株与已发表菌株的相关性。从临床标本中共分离出20株自由活动的变形杆菌，其中包括15株棘阿米巴杆菌，3株瓦氏菌和2株哈特曼氏菌。。毒力棘阿米巴菌株被鉴定为 A。 polyphaga 和两株 A。哈切蒂。据我们所知，这是在奥地利首次确定引起角膜炎的 Acanthamoeba 菌株。就其生理特性而言，临床相关分离株与非相关分离株明显不同。确定了三种生理上最不同的菌株（包括一种引起角膜炎的菌株）的18S核糖体DNA序列类型。该高毒力菌株表现出序列类型T6，该序列类型以前未与角膜炎相关。序列数据表明，引起角膜炎的 Acanthamoeba 菌株以及在奥地利的 Acanthamoeba 的非致病性菌株与来自世界其他地区的已公布菌株最相关。此外，我们的研究结果支持这样的假设，即棘阿米巴的致病性是某些菌株的独特能力，而不依赖于建立感染的适当条件。 展开▼

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《Journal of Clinical Microbiology》 |2000年第11期|共5页

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J. Walochnik; E.-M. Haller-Schober; H. K?lli; O. Picher; A. Obwaller; H. Asp?ck;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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6. Discrimination between Clinically Relevant and Nonrelevant Acanthamoeba Strains Isolated from Contact Lens- Wearing Keratitis Patients in Austria [O] . J. Walochnik, E.-M. Haller-Schober, H. Kölli, 2000

机译：奥地利戴隐形眼镜的角膜炎患者分离的临床相关和不相关棘阿米巴菌株的区别

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Discrimination between Clinically Relevant and NonrelevantAcanthamoeba Strains Isolated from Contact Lens- Wearing Keratitis Patients in Austria

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