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首页> 外文期刊>Journal of Clinical Microbiology >Outbreak of Methicillin-Resistant Staphylococcus aureus with Reduced Susceptibility to Glycopeptides in a Parisian Hospital
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Outbreak of Methicillin-Resistant Staphylococcus aureus with Reduced Susceptibility to Glycopeptides in a Parisian Hospital

机译：耐甲氧西林金黄色葡萄球菌暴发，对一家巴黎医院的糖肽敏感性降低

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Epidemiological relationships were investigated between 40 methicillin-resistant Staphylococcus aureus (MRSA) strains with decreased glycopeptide susceptibility isolated from November 1998 to March 1999 from 39 patients (17 infected and 22 colonized patients) in nine wards of the Broussais Hospital, Paris, France. Reduced glycopeptide susceptibility was readily detected on brain heart infusion (BHI) agar containing 6 μg of teicoplanin per ml and on gradient plates, but not by the standard disk diffusion method. The MICs of vancomycin and teicoplanin, determined on BHI agar, were 4 and 8 to 32 μg/ml, respectively (standard antibiotic dilution), and 4 to 8 and 8 to 32 μg/ml, respectively (E-test). All strains were resistant to macrolides, aminoglycosides, tetracycline, rifampin, sulfonamides, and pefloxacin, showed reduced susceptibility to fusidic acid and fosfomycin, and were susceptible to trimethoprim and chloramphenicol. Pulsed-field gel electrophoresis and lysotyping revealed that a multidrug-resistant MRSA clone with decreased susceptibility to glycopeptides has been discretely endemic since at least 1996 in our institution, where it was responsible for an outbreak in November and December 1998.
机译：从1998年11月至1999年3月从Broussais的9个病区分离的40例耐甲氧西林金黄色葡萄球菌（MRSA）糖肽敏感性降低的流行病学关系进行了调查法国巴黎医院。在每毫升含6μg替考拉宁的脑心浸液（BHI）琼脂上和在梯度板上可以轻松检测到糖肽敏感性降低，但不是通过标准的圆盘扩散法。在BHI琼脂上测定的万古霉素和替考拉宁的MIC分别为4和8至32至32μg/ ml（标准抗生素稀释度）和4至8和8至32至32μg/ ml（E检验）。所有菌株均对大环内酯类，氨基糖苷类，四环素，利福平，磺酰胺和培氟沙星具有抗性，对夫西地酸和磷霉素的敏感性降低，并且对甲氧苄啶和氯霉素敏感。脉冲场凝胶电泳和溶菌分析表明，对糖肽敏感性降低的多药耐药性MRSA克隆自1996年以来就一直是本病的地方流行病，该病原是1998年11月和1998年12月爆发的。

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