Chronic periodontitis is a common infectious disease in the adult population. The etiology is clearly bacterial, and a small number of bacterial species have been consistently associated with periodontitis, including Bacteroides forsythus and Porphyromonas gingivalis. Comparatively little attention has been paid to the identification of health-associated and potentially beneficial bacterial species that may reside in the gingival sulcus. The purpose of the present study was to examine the relationship of the presence of B. forsythus and a newly identified Bacteroides phylotype, oral clone BU063, to periodontal health status. The study was accomplished with a set of samples that were collected from subjects with periodontitis and healthy controls. These samples had previously been analyzed for the presence of P. gingivalis. An oral sampling strategy that included every tooth and a PCR-based detection method were used to maximize detection sensitivity. The presence of B. forsythus in the oral cavity was strongly associated with periodontitis, and its nearest genetic neighbor, oral clone BU063, was associated with oral health (P < 0.0001 for both). Colonization with P. gingivalis was independent of the presence of either Bacteroides species, but the two Bacteroides species were found together less often than would be expected by chance (P < 0.0001). This suggests the presence of a specific exclusionary mechanism between the two Bacteroides species. Comparisons between these two organisms may prove useful for studies that determine how B. forsythus functions in the disease process. In addition, oral clone BU063 deserves further study as a possible preventive or therapeutic intervention for periodontitis.
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机译：慢性牙周炎是成年人口中常见的传染病。病因显然是细菌，少数细菌种类与牙周炎一直存在关联，包括 Bacteroides forsythus 和 Porphyromonas gingivalis 。相对较少的注意力集中在识别可能存在于牙龈沟中的健康相关细菌和潜在有益细菌。本研究的目的是检查 B的存在的关系。连翘和新近鉴定的拟杆菌系统型，口服克隆BU063，对牙周健康状况的影响。这项研究是通过从牙周炎受试者和健康对照组中收集的一组样品完成的。先前已经分析了这些样品中是否存在 P。牙龈炎。包括每个牙齿的口腔采样策略和基于PCR的检测方法被用于最大化检测灵敏度。 B的存在。口腔中的连翘与牙周炎密切相关，其最近的遗传邻居口腔克隆BU063与口腔健康有关（两者均 P <0.0001）。用 P定居。牙龈炎与任何一种拟杆菌物种无关，但是发现两种拟杆菌物种在一起的频率比偶然预期的要少（ P <0.0001）。这表明在两个拟杆菌物种之间存在特定的排斥机制。这两种生物之间的比较可能对确定 B 方式的研究有用。 连翘在疾病过程中起作用。此外，口服克隆BU063作为牙周炎的一种可能的预防或治疗干预措施值得进一步研究。
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