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首页> 外文期刊>Journal of Clinical Microbiology >IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis
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IS6110-Mediated Deletion Polymorphism in Isogenic Strains of Mycobacterium tuberculosis

机译:IS6110介导的结核分枝杆菌同基因菌株中的缺失多态性

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Previous studies have described IS6110-mediated polymorphism as an important driving force in Mycobacterium tuberculosis genome evolution and have provided indirect evidence for IS6110-driven deletion events. This study provides the first description of an IS6110-mediated deletion event in truly isogenic strains. We also provide further support for the hypothesis that the region from Rv1754 to Rv1765 is a hot spot for IS6110 insertion and deletion events.
机译:先前的研究将IS 6110 介导的多态性描述为结核分枝杆菌基因组进化的重要驱动力,并为IS 6110 驱动的间接证据提供了证据。删除事件。这项研究首次描述了真正的同基因菌株中IS 6110 介导的缺失事件。我们还为从Rv1754到Rv1765的区域是IS 6110 插入和缺失事件的热点这一假设提供了进一步的支持。

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