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首页> 外文期刊>Journal of Clinical Microbiology >Six-Month Multicenter Study on Invasive Infections Due to Group B Streptococci in Argentina
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Six-Month Multicenter Study on Invasive Infections Due to Group B Streptococci in Argentina

机译：阿根廷B组链球菌引起的侵袭性感染的六个月多中心研究

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There is little information about invasive infections by group B streptococci (GBS) and their antimicrobial susceptibilities in Latin America. We performed a prospective multicenter study to determine the serotype distribution and the antimicrobial susceptibility of GBS in Argentina. We identified 58 cases, but only 44 had sufficient data to be evaluated. Eight early-, four late-, and one fatal late, late-onset neonatal infections due to GBS were found. A total of 31 patients were adults with bacteremia, skin and soft tissue infections, osteomyelitis, arthritis, meningitis, abdominal infections, and renal abscess. Serotype III was prevalent in late-onset neonatal disease, and several serotypes (Ia/c, III, Ia, and II) were involved in early-onset neonatal infections. Serotypes II, Ia/c, III, and IV were commonly found in adults, with serotype II prevalent in younger adults (18 to 69 years old) and serotype Ia/c prevalent in elderly adults (>70 years old). The mortality rate attributable to GBS infections was 10.8%. All GBS were susceptible to penicillin and ceftriaxone. Resistance to clindamycin (1.7%), erythromycin (5.2%), azithromycin (5.2%), minocycline (69%), and tetracycline (72.4%), to high levels of kanamycin and amikacin (1.7%), and to intermediately high levels of gentamicin (1.7%) was observed. The bifunctional enzyme AAC6′-APH2" was detected in the isolate resistant to aminoglycosides, and other genetic determinants were identified in other resistant isolates: tetM and tetO in tetracycline-resistant streptococci and mefA and ermTR for efflux-mediated and inducible macrolide-lincosamide-streptogramin B-resistant streptococci, respectively. For clinical purposes and rapid and easy detection of high-level aminoglycoside-resistant GBS, a screening method that used 1,000-μg kanamycin disks is proposed.
机译：关于B组链球菌（GBS）的侵袭性感染及其在拉丁美洲的药敏性的信息很少。我们进行了一项前瞻性多中心研究，以确定阿根廷GBS的血清型分布和抗菌药敏性。我们确定了58例，但只有44例有足够的数据可以评估。发现了因GBS导致的8例早期，4例晚期和1例致命的晚期，迟发性新生儿感染。共有31例患者为成人，其中有菌血症，皮肤和软组织感染，骨髓炎，关节炎，脑膜炎，腹部感染和肾脓肿。血清型III在早期发病的新生儿疾病中很普遍，并且几种血清型（Ia / c，III，Ia和II）参与了早期的新生儿感染。 II型，Ia / c，III和IV型血清型常见于成年人，II型血清型在年轻人（18至69岁）中普遍存在，而Ia / c型血清型在老年人（> 70岁以上）中普遍存在。归因于GBS感染的死亡率为10.8％。所有GBS均易受青霉素和头孢曲松钠的影响。对克林霉素（1.7％），红霉素（5.2％），阿奇霉素（5.2％），米诺环素（69％）和四环素（72.4％），高水平的卡那霉素和丁胺卡那霉素（1.7％）以及中等水平的耐药性观察到庆大霉素（1.7％）。在对氨基糖苷类耐药的菌株中检测到双功能酶AAC6'-APH2“，在其他对四环素耐药的链球菌耐药菌株中也鉴定出其他遗传决定因素： tetM 和 tetO 和 mefA 和 ermTR 分别用于外流介导的和诱导性的大环内酯-林可酰胺-链霉菌素对B耐药的链球菌，用于临床目的以及快速简便地检测高水平氨基糖苷类耐药GBS，提出了一种使用1,000μg卡那霉素圆盘的筛选方法。

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