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首页> 外文期刊>Journal of Clinical Microbiology >Helicobacter cetorum sp. nov., a Urease-Positive Helicobacter Species Isolated from Dolphins and Whales
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Helicobacter cetorum sp. nov., a Urease-Positive Helicobacter Species Isolated from Dolphins and Whales

机译：幽门螺杆菌十一月，从海豚和鲸鱼中分离出的脲酶阳性幽门螺杆菌

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A novel helicobacter with the proposed name Helicobacter cetorum, sp. nov. (type strain MIT 99-5656; GenBank accession number AF 292378), was cultured from the main stomach of two wild, stranded Atlantic white-sided dolphins (Lagenorhynchus acutus) and from the feces of three captive cetaceans (a Pacific white-sided dolphin [Lagenorhynchus obliquidens]; an Atlantic bottlenose dolphin [Tursiops truncatus]; and a beluga whale [Delphinapterus leucas]). The infected captive cetaceans were either subclinical, or clinical signs included intermittent regurgitation, inappetance, weight loss, and lethargy. Ulcers were observed in the esophagus and forestomach during endoscopic examination in two of the three captive animals. In the third animal, esophageal linear erosions were visualized endoscopically, and histopathological evaluation of the main stomach revealed multifocal lymphoplasmacytic gastritis with silver-stained spiral-shaped bacteria. Helicobacter cetorum is a fusiform gram-negative bacterium with a single bipolar flagellum. The isolates grow under microaerobic conditions at 37 and 42°C but not at 25°C. H. cetorum is urease, catalase, and oxidase positive, and it is sensitive to cephalothin. The isolates from the wild, stranded dolphins were sensitive to nalidixic acid, whereas the isolates from the collection animals were resistant. By 16S rRNA sequencing it was determined that H. cetorum represented a distinct taxon that clusters most closely with H. pylori. Further studies are necessary to determine the role of H. cetorum in the development of gastric ulcers and gastritis of cetaceans. This is the first description and formal naming of a novel Helicobacter species from a marine mammal.
机译：一种新的幽门螺杆菌，其提议名称为 ceicoum cetorum 。十一月（型号MIT 99-5656; GenBank登录号AF 292378），是从两只野生的，搁浅的大西洋白面海豚（ Lagenorhynchus acutus ）的主胃和三只圈养鲸类动物的粪便中培养的（太平洋白海豚[ Lagenorhynchus obliquidens ];大西洋宽吻海豚[ Tursiops truncatus ];白鲸[[em> Delphinapterus leucas ]] ）。被感染的圈养鲸类动物属于亚临床，或临床症状包括间歇性反流，食欲不振，体重减轻和嗜睡。在三只圈养动物中的两只内窥镜检查过程中，在食道和前胃中发现了溃疡。在第三只动物中，在内窥镜下观察到食管线性糜烂，对主要胃的组织病理学评估显示，多灶性淋巴浆细胞性胃炎伴有银染的螺旋形细菌。幽门螺杆菌是一种梭形革兰氏阴性细菌，带有单个双极鞭毛。分离株在37和42°C的微有氧条件下生长，但在25°C不能生长。 H。 cetorum 为脲酶，过氧化氢酶和氧化酶阳性，对头孢噻吩敏感。野生，滞留海豚的分离株对萘啶酸敏感，而收集动物的分离株具有抗性。通过16S rRNA测序确定 H。 cetorum 代表了一个独特的分类单元，与 H最紧密地聚集在一起。幽门螺杆菌。需要进一步研究以确定 H的作用。 cetorum 与鲸类动物胃溃疡和胃炎的发展。这是对来自海洋哺乳动物的新型 Helicobacter 物种的首次描述和正式命名。

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