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首页> 外文期刊>Journal of Clinical Microbiology >Evaluation of Etest Method for Determining Voriconazole and Amphotericin B MICs for 162 Clinical Isolates of Cryptococcus neoformans
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Evaluation of Etest Method for Determining Voriconazole and Amphotericin B MICs for 162 Clinical Isolates of Cryptococcus neoformans

机译：测定伏立康唑和两性霉素B MICs 162株新隐球菌临床分离株的试验方法的评价

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The performance of the Etest for voriconazole and amphotericin B susceptibility testing of 162 isolates of Cryptococcus neoformans was assessed against the National Committee for Clinical Laboratory Standards (NCCLS) broth microdilution method. The NCCLS method employed RPMI 1640 broth medium, and MICs were read after incubation for 72 h at 35°C. MICs were determined by Etest for all 162 isolates with RPMI 1640 agar containing 2% glucose (RPG agar) and were read after incubation for 72 h at 35°C. The Etest results for both voriconazole and amphotericin B correlated well with reference MICs. Agreement was 94% for voriconazole and 99% for amphotericin B. When discrepancy was noted between the results obtained by Etest and broth microdilution for voriconazole, the Etest generally provided a higher MIC. The Etest method using RPG agar appears to be a useful method for determining the susceptibility of C. neoformans to voriconazole and amphotericin B.
机译：根据国家临床实验室标准委员会（NCCLS）肉汤微量稀释方法，对162株新产隐球菌的伏立康唑和两性霉素B药敏试验的Etest性能进行了评估。 NCCLS方法使用RPMI 1640肉汤培养基，在35°C孵育72小时后读取MIC。通过Etest测定所有162个含2％葡萄糖的RPMI 1640琼脂（RPG琼脂）分离株的MIC，并在35°C孵育72小时后读取。伏立康唑和两性霉素B的Etest结果与参考MIC密切相关。伏立康唑的一致性为94％，两性霉素B的一致性为99％。当注意到Etest的结果与伏立康唑的肉汤微量稀释之间存在差异时，Etest通常提供较高的MIC。使用RPG琼脂的Etest方法似乎是确定 C敏感性的有用方法。新甲虫转化为伏立康唑和两性霉素B。

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