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首页> 外文期刊>Journal of Clinical Microbiology >Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan
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Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan

机译：日本幽门螺杆菌中cag致病岛的独特多样性

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摘要

The severity of Helicobacter pylori-related disease is correlated with the presence of a cag pathogenicity island (PAI). Genetic diversity within the cag PAI may have a modifying effect on the pathogenic potential of the infecting strain. We analyzed the complete cag PAI sequences of 11 representative Japanese strains according to their vacA genotypes and clinical effects and examined the relationship between the diversity of the cag PAI and clinical features. The cag PAI genes were divided into two major groups, a Western and a Japanese group, by phylogenetic analysis based on the entire cag PAI sequences. The predominant Japanese strains formed a Japanese cluster which was different from the cluster formed by Western strains. The diversity of the cag PAI was associated with the vacA and cagA genotypes. All strains with the s1c vacA genotype were in the Japanese cluster. In addition, all strains with the East Asian-type cagA genotype were also in the Japanese cluster. Patients infected with the Japanese-cluster strain had high-grade gastric mucosal atrophy. These results suggest that a distinct diversity of the cag PAI of H. pylori is present among Japanese strains and that this diversity may be involved in the development of atrophic gastritis and may increase the risk for gastric cancer.
机译：幽门螺杆菌相关疾病的严重程度与 cag 致病岛（PAI）的存在有关。 cag PAI内的遗传多样性可能会对感染菌株的致病性产生影响。我们根据11种代表性日本菌株的 vacA 基因型和临床效果分析了完整的 cag PAI序列，并检验了 cag PAI和临床特征。根据整个 cag PAI序列，通过系统进化分析将 cag PAI基因分为两个主要组，西方和日本组。主要的日本菌株形成了与西方菌株形成的簇不同的日本簇。 cag PAI的多样性与 vacA 和 cagA 基因型相关。所有具有s1c vacA 基因型的菌株都在日本群中。此外，所有具有东亚型 cagA 基因型的菌株也都在日本群中。感染日本群菌株的患者出现严重的胃粘膜萎缩。这些结果表明， H的 cag PAI具有明显的多样性。幽门螺杆菌存在于日本菌株中，这种多样性可能与萎缩性胃炎的发展有关，并可能增加患胃癌的风险。

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