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首页> 外文期刊>Journal of Clinical Microbiology >High Frequency of Human Enterovirus Species C Circulation in Madagascar
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High Frequency of Human Enterovirus Species C Circulation in Madagascar

机译：马达加斯加的人类肠道病毒种类C循环的高频率

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Four poliomyelitis outbreaks caused by vaccine-derived polioviruses have been reported recently, including one in Madagascar in 2002. In all cases, the viral strains involved were recombinant between poliovirus vaccine strains and nonpoliovirus strains, probably enterovirus species C. Nevertheless, little is known about the circulation and epidemiology of enteroviruses in the regions where these outbreaks occurred. To assess the circulation of enteroviruses (particularly enterovirus species C) in Madagascar, we genetically characterized 55 enterovirus strains isolated between 1994 and 2002. The strains were identified and compared by partially sequencing the region encoding the VP1 capsid protein. Phylogenetic analysis and pairwise comparison with prototype enterovirus strains distinguished two different species: 25 isolates belonged to human enterovirus B species, and 30 isolates were identified as coxsackievirus A13, A15, A17, A18, A20, A21, and A24, belonging to the human enterovirus species C. The relatively high frequency and the wide distribution of species C coxsackie A viruses in different regions of Madagascar suggest that they had been silently and widely circulating in the country during the whole study period. The circulation of coxsackie A viruses, combined with the low routine oral polio vaccine coverage, may have played a role in the emergence of the recent outbreak in Madagascar.
机译：最近报道了由疫苗衍生的脊髓灰质炎病毒引起的四次脊髓灰质炎暴发，包括2002年在马达加斯加的一次。在所有情况下，所涉及的病毒株都是脊髓灰质炎病毒疫苗株和非脊髓灰质炎病毒株之间的重组体，可能是肠道病毒种C。这些爆发发生地区的肠道病毒的流行和流行病学。为了评估马达加斯加的肠道病毒（特别是肠道病毒C型）的流通，我们对1994年至2002年之间分离出的55株肠道病毒菌株进行了遗传鉴定。通过部分测序编码VP1衣壳蛋白的区域，对菌株进行了鉴定和比较。系统发育分析和成对比较原型肠病毒株区分两个不同的物种：25属于人类肠病毒B物种的分离株，和30分离株被鉴定为柯萨奇病毒A13，A15，A17，A18，A20，A21和A24，属于人肠道病毒柯萨奇A型C病毒在马达加斯加不同地区的发生频率较高且分布广泛，这表明它们在整个研究期间一直在该国无声且广泛传播。柯萨奇A病毒的传播，加上常规的口服脊髓灰质炎疫苗覆盖率低，可能在马达加斯加最近爆发的疫情中发挥了作用。

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