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首页> 外文期刊>Journal of Clinical Microbiology >Extremely High Incidence of Macrolide and Trimethoprim-Sulfamethoxazole Resistance among Clinical Isolates ofStreptococcus pneumoniae in Taiwan
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Extremely High Incidence of Macrolide and Trimethoprim-Sulfamethoxazole Resistance among Clinical Isolates ofStreptococcus pneumoniae in Taiwan

机译：台湾肺炎链球菌临床分离株对大环内酯类和甲氧苄啶-磺胺甲基异恶唑耐药的发生率极高

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From January 1996 to December 1997, 200 isolates ofStreptococcus pneumoniae recovered from 200 patients treated at National Taiwan University Hospital were serotyped and their susceptibilities to 16 antimicrobial agents were determined by the agar dilution method. Sixty-one percent of the isolates were nonsusceptible to penicillin, exhibiting either intermediate resistance (28%) or high-level resistance (33%). About two-fifths of the isolates displayed intermediate or high-level resistance to cefotaxime, ceftriaxone, cefepime, imipenem, and meropenem. Extremely high proportions of the isolates were resistant to erythromycin (82%), clarithromycin (90%), and trimethoprim-sulfamethoxazole (TMP-SMZ) (87%). Among the isolates nonsusceptible to penicillin, 23.8% were resistant to imipenem; more than 60% displayed resistance to cefotaxime, ceftriaxone, cefepime, and carbapenems; 96.7% were resistant to erythromycin; and 100% were resistant to TMP-SMZ. All isolates were susceptible to rifampin and vancomycin. The MICs at which 50% and 90% of the isolates were inhibited were 0.12 and 1 μg/ml, respectively, for cefpirome, and 0.12 and 0.25 μg/ml, respectively, for moxifloxacin. Six serogroups or serotypes (23F, 19F, 6B, 14, 3, and 9) accounted for 77.5% of all isolates. Overall, 92.5% of the isolates were included in the serogroups or serotypes represented in the 23-valent pneumococcal vaccine. The incidence of macrolide and TMP-SMZ resistance for S. pneumoniae isolates in Taiwan in this study is among the highest in the world published to date.
机译：从1996年1月至1997年12月，对从台湾大学医院收治的200例患者中分离出的200株肺炎链球菌进行了血清分型，并通过琼脂稀释法确定了它们对16种抗菌药的敏感性。 61％的分离株对青霉素不敏感，表现出中等耐药性（28％）或高水平耐药性（33％）。大约五分之二的分离株对头孢噻肟，头孢曲松，头孢吡肟，亚胺培南和美罗培南表现出中等或高水平抗性。极高比例的分离株对红霉素（82％），克拉霉素（90％）和甲氧苄啶-磺胺甲基恶唑（TMP-SMZ）（87％）有抗性。在对青霉素不敏感的分离物中，对亚胺培南有23.8％的耐药性。超过60％的人对头孢噻肟，头孢曲松，头孢吡肟和碳青霉烯类药物表现出抗药性; 96.7％的人对红霉素有抗药性; 100％对TMP-SMZ有抗性。所有分离株均对利福平和万古霉素敏感。头孢哌酮对MIC的抑制率分别为50％和90％，MIC分别为0.12和1μg/ ml，莫西沙星的MIC分别为0.12和0.25μg/ ml。六个血清群或血清型（23F，19F，6B，14、3和9）占所有分离株的77.5％。总体而言，在23价肺炎球菌疫苗所代表的血清群或血清型中包括92.5％的分离株。 S对大环内酯和TMP-SMZ耐药的发生率。在这项研究中，台湾的肺炎链球菌分离株是迄今已发表的世界上最高的肺炎球菌之一。

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