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首页> 外文期刊>Journal of Clinical Microbiology >Sequence Polymorphism of the 16S rRNA Gene of Vibrio vulnificus Is a Possible Indicator of Strain Virulence
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Sequence Polymorphism of the 16S rRNA Gene of Vibrio vulnificus Is a Possible Indicator of Strain Virulence

机译:创伤弧菌16S rRNA基因的序列多态性可能是菌株毒力的指标。

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Vibrio vulnificus exhibits considerable strain-to-strain variation in virulence. Attempts to associate phenotypic or genotypic characteristics with strain virulence have been largely unsuccessful. Based on a 17-nucleotide difference throughout the sequence of the small subunit 16S rRNA gene, there are two major groups of V. vulnificus designated types A and B. In a survey of the 16S rRNA genotype in 67 V. vulnificus human clinical and nonclinical strains, we determined that the majority of nonclinical isolates are type A (31 of 33) and that there is a statistically significant association between the type B genotype and human clinical strains (26 of 34).
机译:创伤弧菌在毒力方面表现出很大的株间差异。将表型或基因型特征与毒株毒力相关联的尝试在很大程度上没有成功。基于16S rRNA小亚基整个序列的17个核苷酸差异,有两个主要的 V组。 vulnificus 被指定为A型和B型。在一项对67 V型中16S rRNA基因型的调查中。我们确定人类非临床菌株和非临床菌株中,大多数非临床分离株均为A型(33个中的31个),B型基因型与人类临床菌株之间存在统计学上的显着关联(26个中的34个)。

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