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首页> 外文期刊>Journal of Clinical Microbiology >Changes in Gene Cassettes of Class 1 Integrons among Escherichia coli Isolates from Urine Specimens Collected in Korea during the Last Two Decades
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Changes in Gene Cassettes of Class 1 Integrons among Escherichia coli Isolates from Urine Specimens Collected in Korea during the Last Two Decades

机译：最近两个十年来韩国收集的尿液标本中大肠埃希菌分离株中1类整合子的基因盒的变化

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Gene cassettes of class 1 integrons in Escherichia coli isolates from urine specimens collected in Korea during the last 2 decades were characterized. intI1 was detected in 54% of the isolates, yet gene cassette regions were amplified in only 43% of the isolates. intI2 was detected in 29 (5%) isolates, and no intI3 was detected in this study. Twenty-one different genes, including genes encoding resistance to antibiotics, an alcohol dehydrogenase gene (adhE), and unknown genes, were detected. The genes most commonly found in class 1 integrons were those for aminoglycoside and trimethoprim resistance. The occurrence of aminoglycoside resistance genes in class 1 integrons decreased, and the presence of dfr genes increased rapidly, during the last 2 decades. Single-gene cassettes were predominant during the 1980s, while multigene cassettes predominated from the 1990s on. The aadA1, aadA2, and blaP1-aadA2 gene cassettes were frequently found in isolates from the 1980s but were not detected in isolates recovered since 2000. dfrA12-aadA2 and dfrA17-aadA5 were the most prevalent gene cassettes among isolates recovered from the 1990s on. In conclusion, class 1 integrons would appear to be responsible for resistance to antibiotics commonly used to treat urinary tract infections, and selection of a specific gene cassette was found to occur over the course of time.
机译：对过去20年间在韩国收集的尿液样本中的大肠杆菌分离物中的1类整合素的基因盒进行了表征。在54％的分离物中检测到 intI1 ，而仅43％的分离物扩增了基因盒区域。在29个（5％）分离物中检测到 intI2 ，并且在此研究中未检测到 intI3 。检测到21种不同的基因，包括编码对抗生素耐药的基因，酒精脱氢酶基因（ adhE ）和未知基因。在1类整合素中最常见的基因是氨基糖苷和甲氧苄啶抗性基因。在最近的20年中，1类整合素中氨基糖苷抗性基因的出现减少，而 dfr 基因的存在迅速增加。单基因盒在1980年代占主导地位，而多基因盒在1990年代开始占主导地位。 aadA1 ， aadA2 和 blaP1-aadA2 基因盒通常在1980年代的分离株中发现，但自2000年以来回收的分离株中未发现。在1990年代以来回收的分离株中， dfrA12-aadA2 和 dfrA17-aadA5 是最流行的基因盒。总之，1类整合素似乎是对通常用于治疗尿路感染的抗生素产生耐药性的原因，并且发现特定基因盒的选择会随着时间的流逝而发生。

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