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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Analysis of Burkholderia cepacia Complex Isolates from a Portuguese Cystic Fibrosis Center: a 7-Year Study
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Molecular Analysis of Burkholderia cepacia Complex Isolates from a Portuguese Cystic Fibrosis Center: a 7-Year Study

机译：来自葡萄牙囊性纤维化中心的洋葱伯克霍尔德菌洋葱复合体分离物的分子分析：历时7年的研究

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摘要

This work reports results of a systematic molecular analysis involving 113 Burkholderia cepacia complex isolates obtained from 23 cystic fibrosis (CF) patients under surveillance over a 7-year period at the major Portuguese CF center, the Santa Maria Hospital in Lisbon. The majority of the isolates were serial isolates from persistently infected patients (more than one-half of the population examined). In agreement with previous studies, B. cenocepacia (formerly genomovar III) was the most prevalent species; it was isolated from 52% of the patients infected with B. cepacia complex isolates. Contrasting with previous studies, a very significant percentage of the Portuguese CF subpopulation examined was infected with B. cepacia genomovar I (36%) and B. stabilis (18%). B. multivorans was recovered from two of the infected patients. All four of the species or genomovars were associated with poor clinical outcome, including the cepacia syndrome, and gave rise to chronic and transient infections, with the clinical condition depending on the patient and other still-unidentified factors. The B. cepacia epidemic strain marker region was found exclusively in genomovar III strains, while cblA was detected in genomovars I and III, only. There was no clear relation between the presence of these markers and transmissibility. Altogether, our results indicate that the use of these markers or the genomovar status in identifying patients at higher risk for infection is uncertain.
机译：这项工作报告了一项系统的分子分析结果，该分析涉及从葡萄牙主要CF中心Santa Maria Hospital进行的7年期监视下的23例囊性纤维化（CF）患者中分离得到的113株伯克霍尔德氏菌复杂样本在里斯本。大多数分离株是来自持续感染患者的串行分离株（超过一半的受检人群）。与以前的研究一致， B。 cenocepacia （以前的Genomovar III）是最流行的物种。它是从52％感染 B的患者中分离出来的。 cepacia 复杂菌株。与先前的研究相反，所检查的葡萄牙CF亚群中有很大一部分感染了 B。 ceepacia genomovar I（36％）和 B。稳定（18％）。 B。从两名受感染的患者中发现了多菌落。这四个物种或基因组的所有患者均与差的临床结果相关，包括cepacia综合征，并引起了慢性和短暂性感染，其临床状况取决于患者和其他尚不确定的因素。 B。 cepacia 流行株标记区域仅在genomovar III菌株中发现，而 cblA 仅在genomovar I和III中发现。这些标记物的存在与透射率之间没有明确的关系。总之，我们的结果表明，使用这些标记物或基因组状态来确定感染风险较高的患者尚不确定。

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