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首页> 外文期刊>Journal of Clinical Microbiology >Trichosporon loubieri Infection in a Patient with Adult Polycystic Kidney Disease
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Trichosporon loubieri Infection in a Patient with Adult Polycystic Kidney Disease

机译：成人多囊肾患者中的Trichosporon loubieri感染

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A 45-year-old man from Nepal with a 13-year history of polycystic kidney disease was diagnosed as suffering from chronic renal failure with end-stage renal disease. After receiving empirical antituberculosis treatment, he was treated with broad-spectrum antibiotics. A left nephrectomy was performed, and after 4 months, he received a kidney transplant. The left kidney was grossly enlarged, with multiple cystic spaces filled with blackish material. Histologic examination of the excised left kidney tissue stained with hematoxylin and eosin and Gomori's methenamine silver stains showed numerous hyaline, septate, fungal hyphae of various lengths, many broken into rectangular arthroconidia in the cystic spaces. Culture of the kidney tissue yielded white, glabrous, yeast-like colonies. Based on its micromorphology, growth at 42°C, and ribosomal DNA (rDNA) sequence analysis, and also sequence analysis of the internal-transcribed-spacer and D1/D2 rDNA regions, the yeast was identified as Trichosporon loubieri. Postsurgically, the patient was treated with amphotericin B and oral itraconazole, followed by maintenance therapy with fluconazole. He remained afebrile and asymptomatic. At the final follow-up, all parameters were found normal and the patient was doing well, with normal renal function reports. This paper presents the first known case of human infection caused by T. loubieri.
机译：来自尼泊尔的一名45岁男子，患有多囊肾病已有13年的历史，被诊断为患有终末期肾脏疾病的慢性肾功能衰竭。在接受经验性抗结核治疗后，他接受了广谱抗生素治疗。进行了左肾切除术，四个月后，他接受了肾脏移植。左肾明显肿大，多个囊性间隙充满黑色物质。对切​​除的左肾组织进行苏木精和曙红染色以及Gomori的二甲胺银染色的组织学检查显示，有许多透明的，分隔的，真菌性的菌丝，长度各不相同，许多在囊性空间中破碎成矩形的关节炎。肾脏组织的培养产生白色的，无毛的，酵母样菌落。根据其微观形态，在42°C下的生长以及核糖体DNA（rDNA）序列分析以及内部转录间隔区和D1 / D2 rDNA区域的序列分析，该酵母被鉴定为 Trichosporon loubieri。< / em>术后，患者接受两性霉素B和口服伊曲康唑治疗，然后接受氟康唑维持治疗。他保持发热和无症状。在最后的随访中，所有参数均正常且患者情况良好，肾功能报告正常。本文介绍了由 T引起的第一个已知的人类感染病例。卢比耶。

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