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首页> 外文期刊>Journal of Clinical Microbiology >Antigenic and genetic variation in Legionella pneumophila serogroup 6.
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Antigenic and genetic variation in Legionella pneumophila serogroup 6.

机译：嗜肺军团菌血清群6的抗原和遗传变异

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Legionella pneumophila subsp. pneumophila serogroup 6 is second in importance only to L. pneumophila serogroup 1 as a cause of legionellosis. Monoclonal antibody (MAb) reactivity and multilocus enzyme electrophoretic analyses were used to subtype serogroup 6 isolates as a potential aid for epidemiologic and virulence studies. Forty-eight serogroup 6 isolates submitted to the Centers for Disease Control from 1980 to 1985 were examined by these methods. The isolates were divided into two groups based on differential reactivity with two MAbs. Thirty-two of the isolates were of a single electrophoretic type (ET) and were reactive with both MAbs. The remaining 16 isolates were distributed among 10 ETs and were reactive with one or both MAbs. The mean genetic diversity for serogroup 6, as determined from the degree of variability at 20 enzyme loci, was found to be essentially the same as that for L. pneumophila subsp. pneumophila as a whole. The ETs of serogroup 6 isolates were unique but closely related genetically to the ETs of L. pneumophila subsp. pneumophila serogroups 1 to 5, 7, and 8. The range of serogroup 6 subtypes distinguished by MAbs and enzyme electrophoresis suggests that the combination of these two methods can be useful as a typing system.
机译：嗜肺军团菌亚种。作为军团菌病的原因，肺炎嗜血菌血清群6仅次于肺炎嗜血杆菌血清群1重要。单克隆抗体（MAb）反应性和多位酶电泳分析被用于血清型6分离株的亚型，作为流行病学和毒力研究的潜在辅助手段。通过这些方法检查了1980年至1985年提交给疾病控制中心的48个血清群6分离株。基于与两种MAb的差异反应性，将分离物分为两组。其中的32种分离物属于单一电泳类型（ET），与两种单克隆抗体均具有反应性。其余的16个分离株分布在10个ET之间，并与一个或两个MAb发生反应。由20个酶基因座的变异程度确定的血清群6的平均遗传多样性被发现与嗜肺乳杆菌亚种基本相同。整个肺炎。血清群6分离株的ETs是独特的，但在遗传上与嗜肺乳杆菌亚种的ETs密切相关。肺炎嗜血杆菌血清群1至5、7和8。通过MAb和酶电泳区分的血清群6亚型范围表明，这两种方法的组合可用作打字系统。

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