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首页> 外文期刊>Journal of Clinical Microbiology >Distribution of viral genotypes in Italy determined by hepatitis C virus typing by DNA immunoassay.
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Distribution of viral genotypes in Italy determined by hepatitis C virus typing by DNA immunoassay.

机译：DNA免疫测定法通过丙型肝炎病毒分型确定了意大利病毒基因型的分布。

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摘要

The distribution of hepatitis C virus (HCV) genotypes in Italy was investigated by PCR amplification of the E1 region and hybridization with type I- and type II-specific nonisotopic probes. Positive PCR results were obtained for 65 of 72 patients (90.3%). Type I was detected in 13 of 72 patients (18%), type II was detected in 39 patients (54.2%), and a mixed type I-type II infection was detected in 7 patients (9.7%). Six amplification products not classified by this method shared a low level of homology with HCV types I and II. HCV type I was significantly associated with human immunodeficiency virus, whereas HCV type II was detected in older subjects who were negative for human immunodeficiency virus markers. These results indicate different epidemiological distributions of HCV types I and II in Italy.
机译：通过PCR扩增E1区并与I型和II型特异性非同位素探针杂交，研究了意大利丙型肝炎病毒（HCV）基因型的分布。 72例患者中有65例（90.3％）获得了阳性PCR结果。在72例患者中有13例（18％）被检出I型，在39例患者（54.2％）检出了II型，在7例患者中检出了I型混合感染（9.7％）。六种未通过此方法分类的扩增产物与I型和II型HCV具有较低的同源性。 HCV I型与人类免疫缺陷病毒显着相关，而HCV II型在人类免疫缺陷病毒标记阴性的老年受试者中检测到。这些结果表明意大利的I型和II型HCV流行病学分布不同。

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