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首页> 外文期刊>Journal of Clinical Microbiology >Subtype 2c of hepatitis C virus is highly prevalent in Italy and is heterogeneous in the NS5A region.
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Subtype 2c of hepatitis C virus is highly prevalent in Italy and is heterogeneous in the NS5A region.

机译：丙型肝炎病毒2c亚型在意大利非常普遍，在NS5A地区异质。

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Hepatitis C virus (HCV) isolates, obtained from 50 Italian patients with community-acquired infection, that had previously been classified as subtype 2a or 2b by current rapid genotyping methods were further characterized by partial sequence analysis. All the isolates were reclassified: 45 within subtype 2c and the other 5 as subtype 1b, 3a, or 4d. Thus, subtype 2c is much more prevalent than previously recognized, with about 30% of all HCV strains detected in Italy being subtype 2c. In contrast, isolates of subtypes 2a and 2b appear to be infrequent, if not absent. Further studies showed that subtype 2c isolates are heterogeneous in the NS5A region, in that they may or may not contain a 57-nucleotide (nt) segment spanning from nt 7533 to nt 7589 of the viral genome. Partial nucleotide sequencing of the NS5B region of four 2c subtypes excluded the possibility that the isolates possessing or not possessing the 57-nt segment in the NS5A region may have resulted from recombination phenomena.
机译：通过部分序列分析进一步表征了从50例意大利社区获得性感染患者中获得的丙型肝炎病毒（HCV）分离株，这些患者先前已通过当前的快速基因分型方法划分为2a或2b亚型。所有的分离物都被重新分类：亚型2c中有45个，其他5个中亚型1b，3a或4d。因此，亚型2c比以前公认的流行得多，在意大利检测到的所有HCV毒株中约有30％是亚型2c。相反，亚型2a和2b的分离株似乎很少见，甚至不存在。进一步的研究表明，亚型2c分离株在NS5A区域内是异质的，因为它们可能包含也可能不包含病毒基因组中从7533核苷酸到7589核苷酸的57核苷酸（nt）片段。对四个2c亚型的NS5B区进行部分核苷酸测序，排除了重组现象中NS5A区具有或不具有57-nt片段的分离株的可能性。

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