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首页> 外文期刊>Journal of Clinical Microbiology >Incidence of Toxoplasma gondii Infection in 35,940 Pregnant Women in Norway and Pregnancy Outcome for Infected Women
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Incidence of Toxoplasma gondii Infection in 35,940 Pregnant Women in Norway and Pregnancy Outcome for Infected Women

机译：挪威35,940名孕妇的弓形虫感染发生率和受感染妇女的妊娠结局

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From 1992 to 1994 a screening program for detection of specific Toxoplasma gondii antibodies involving 35,940 pregnant women was conducted in Norway. For women with serological evidence of primary T. gondii infection, amniocentesis and antiparasitic treatment were offered. The amniotic fluid was examined for T. gondii by PCR and mouse inoculation to detect fetal infection. Infants of infected mothers had clinical and serological follow-up for at least 1 year to detect congenital infection. Of the women 10.9% were infected before the onset of pregnancy. Forty-seven women (0.17% among previously noninfected women) showed evidence of primary infection during pregnancy. The highest incidence was detected (i) among foreign women (0.60%), (ii) in the capital city of Oslo (0.46%), and (iii) in the first trimester (0.29%). Congenital infection was detected in 11 infants, giving a transmission rate of 23% overall, 13% in the first trimester, 29% in the second, and 50% in the third. During the 1-year follow-up period only one infant, born to an untreated mother, was found to be clinically affected (unilateral chorioretinitis and loss of vision). At the beginning of pregnancy 0.6% of the previously uninfected women were falsely identified as positive by the Platelia Toxo-IgM test, the percentage increasing to 1.3% at the end of pregnancy. Of the women infected prior to pregnancy 6.8% had persisting specific immunoglobulin M (IgM). A positive specific-IgM result had a low predictive value for identifying primaryT. gondii infection.
机译：从1992年到1994年，在挪威实施了一项筛查计划，以检测涉及35,940名孕妇的特异性弓形虫抗体。对于具有原发性T血清学证据的女性。提供了弓形虫感染，羊膜穿刺术和抗寄生虫治疗。检查羊水的T。通过PCR和小鼠接种法检测刚地菌，以检测胎儿感染。被感染母亲的婴儿进行了至少一年的临床和血清学随访，以发现先天性感染。在这些妇女中，有10.9％在怀孕开始之前就被感染了。 47名妇女（以前未感染的妇女中为0.17％）显示出怀孕期间原发感染的证据。在外国女性中（i）（0.60％），（ii）首都奥斯陆（0.46％）和（iii）在头三个月（0.29％）中发现了最高的发病率。在11例婴儿中检测到先天性感染，总体传播率为23％，孕中期为13％，孕中期为29％，孕晚期为50％。在1年的随访期内，仅一名未治疗的母亲出生的婴儿受到临床影响（单侧脉络膜视网膜炎和视力丧失）。在怀孕开始时，Platelia Toxo-IgM测试将0.6％以前未感染的妇女错误地鉴定为阳性，该百分比在怀孕结束时增加到1.3％。在怀孕前被感染的妇女中，有6.8％的人持续存在特异性免疫球蛋白M（IgM）。特异性IgM阳性结果对鉴定原发性T的预测价值低。刚地感染。

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