Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines

Mathew A. Diggle; Stuart C. Clarke

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Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines

机译：引入脑膜炎球菌血清C群多糖结合疫苗后脑膜炎奈瑟氏球菌分离株的遗传多样性增加

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During the 1990s, the incidence of meningococcal disease was high in the United Kingdom. This was due primarily to an increase in serogroup C disease, particularly that within the ET-37/ST-11 genetic lineage. Serogroup C meningococcal polysaccharide conjugate vaccines were introduced in the United Kingdom in 1999, but the sequence types of meningococci causing disease since that time have not yet been reported. We have used serogrouping and multilocus sequence typing to characterize meningococci from patients with invasive disease over a 4-year period and show that there is a significant increase in genetic diversity but no genetic evidence of capsule switching.

机译：在1990年代，英国脑膜炎球菌的发病率很高。这主要是由于C血清群疾病的增加，尤其是ET-37 / ST-11遗传谱系内的疾病。血清群C脑膜炎球菌多糖结合疫苗于1999年在英国引入，但自那时以来尚未报道引起脑膜炎球菌疾病的序列类型。我们已经使用血清分组和多基因座序列分型来表征侵袭性疾病患者在过去四年中的脑膜炎球菌，并表明遗传多样性显着增加，但没有胶囊转换的遗传证据。

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《Journal of Clinical Microbiology》 |2005年第9期|共5页
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Mathew A. Diggle; Stuart C. Clarke;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Induction of Protective Serum Meningococcal Bactericidal and Diphtheria-Neutralizing Antibodies and Mucosal Immunoglobulin A in Volunteers by Nasal Insufflations of the Neisseria meningitidis Serogroup C Polysaccharide-CRM197 Conjugate Vaccine Mixed with Chitosan [J] . Zhiming Huo, Ruchi Sinha, Edel A. McNeela, Infection and immunity . 2005,第12期

机译：脑膜炎奈瑟氏球菌血清群C多糖CRM197与壳聚糖混合疫苗的鼻腔吹入诱导志愿者的保护性血清脑膜炎球菌杀菌和白喉中和抗体和粘膜免疫球蛋白A
2. Young-adult carriers of Neisseria meningitidis in Puglia (Italy): Will the pattern of circulating meningococci change following the introduction of meningococcal serogroup C conjugate vaccines? [J] . Germinario C, Tafuri S, Napoli C, Human vaccines . 2010,第12期

机译：普利亚（意大利）脑膜炎奈瑟氏球菌的年轻成人携带者：引入脑膜炎球菌血清C群结合疫苗后，循环脑膜炎球菌的格局会改变吗？
3. Immunogenicity and Safety of a Multicomponent Meningococcal Serogroup B Vaccine and a Quadrivalent Meningococcal CRM197 Conjugate Vaccine against Serogroups A, C, W-135, and Y in Adults Who Are at Increased Risk for Occupational Exposure to Meningococcal Isolates [J] . Alan Kimura, Daniela Toneatto, Annett Kleinschmidt, Clinical and vaccine immunology: CVI . 2011,第3期

机译：在职业性脑膜炎球菌分离株暴露风险较高的成年人中，多组分脑膜炎球菌血清B群疫苗和四价脑膜炎球菌CRM197的免疫原性和安全性结合疫苗针对A，C，W-135和Y血清群。
4. Fatal meningococcal meningitidis in a baby caused by serogroup C Neisseria meningitidis belonging to ST-4821 complex [C] . Hui Han, Haishan Li, Yu Yang, International Conference on Human Health and Medical Engineering. . 2014

机译：致命的脑膜炎球菌脑膜脑膜脑膜脑膜脑膜炎症患者由Serogroup C Neisseria Meningitidis属于ST-4821复合物
5. Development and characterization of the immune response induced by peptides and DNA constructs that mimic the capsular polysaccharide of Neisseria meningitidis serogroup C. [D] . Prinz, Deborah Marie. 2005

机译：模仿脑膜炎奈瑟氏球菌血清群C的荚膜多糖的肽和DNA构建体诱导的免疫应答的发展和表征。
6. Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines [O] . Mathew A. Diggle, Stuart C. Clarke 2018

机译：引入脑膜炎球菌血清C群多糖结合疫苗后脑膜炎奈瑟氏球菌分离株的遗传多样性增加
7. Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines [O] . Diggle, Mathew A., Clarke, Stuart C. 2005

机译：引入脑膜炎球菌血清C群多糖结合疫苗后脑膜炎奈瑟氏球菌分离株的遗传多样性增加
8. Immunogenicity of Serogroup A and C 'Neisseria meningitidis' Polysaccharide Vaccines Administered Together in Humans. [R] . Brandt, B. L., Smith, C. D., Artenstein, M. S. 1977

机译：血清a和C'脑膜炎奈瑟球菌'多糖疫苗在人体内共同给药的免疫原性。

Increased Genetic Diversity of Neisseria meningitidis Isolates after the Introduction of Meningococcal Serogroup C Polysaccharide Conjugate Vaccines

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