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首页> 外文期刊>Journal of Clinical Microbiology >Single Nucleotide Polymorphisms on the Road to Strain Differentiation in Mycobacterium ulcerans
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Single Nucleotide Polymorphisms on the Road to Strain Differentiation in Mycobacterium ulcerans

机译：溃疡分枝杆菌菌株分化路上的单核苷酸多态性

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The genomic fine-typing of strains of Mycobacterium ulcerans, the causative agent of the emerging human disease Buruli ulcer, is difficult due to the clonal population structure of geographical lineages. Although large sequence polymorphisms (LSPs) resulted in the clustering of patient isolates originating from across the globe, differentiation of strains within continents using conventional typing methods is very limited. In this study, we analyzed M. ulcerans LSP haplotype-specific insertion sequence elements among 83 M. ulcerans strains and identified single nucleotide polymorphisms (SNPs) that differentiate between regional strains. This is the first genetic discrimination based on SNPs of M. ulcerans strains from African countries where Buruli ulcer is endemic, resulting in the highest geographic resolution of genotyping so far. The findings support the concept of genome-wide SNP analyses as tools to study the epidemiology and evolution of M. ulcerans at a local level.
机译：由于地理谱系的克隆种群结构，溃疡分枝杆菌（新兴人类疾病布鲁里溃疡的病原体）菌株的基因组精细分型很难。尽管大序列多态性（LSPs）导致了来自全球的患者分离株的聚集，但是使用常规分型方法在大洲内菌株的分化非常有限。在这项研究中，我们分析了 M。 83 M中溃疡 LSP单倍型特异性插入序列元件溃疡菌株并鉴定出可区分区域菌株的单核苷酸多态性（SNP）。这是基于 M的SNP的第一个遗传歧视。来自布鲁里溃疡流行的非洲国家的溃疡菌株，是迄今为止基因分型的最高地理分辨率。这些发现支持了全基因组SNP分析的概念，将其作为研究 M的流行病学和进化的工具。地方性溃疡。

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