MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples

Evguenia S. Svarovskaia; Michael J. Moser; Andrew S. Bae; James R. Prudent; Michael D. Miller; Katyna Borroto-Esoda

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MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples

机译：用于检测临床样品中K65R人类免疫缺陷病毒1型逆转录酶突变病毒亚群的MultiCode-RTx实时PCR系统

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We report a real-time PCR assay capable of detecting drug-resistant human immunodeficiency virus type 1 reverse transcriptase K65R mutant virus at a level of 0.5% in polymorphic patient plasma specimens. Fifty-three treatment-na?ve and 20 treatment-experienced specimens were successfully genotyped with the new method. Results were in agreement with population sequencing and the labor-intensive single-genome sequencing method.

机译：我们报告了一种实时PCR检测方法，能够检测多态性患者血浆样本中0.5％的抗药性人类免疫缺陷病毒1型逆转录酶K65R突变病毒。用这种新方法成功地对53个初次治疗的标本和20个经历过治疗的标本进行了基因分型。结果与人群测序和劳动密集型单基因组测序方法一致。

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《Journal of Clinical Microbiology》 |2006年第11期|共5页
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Evguenia S. Svarovskaia; Michael J. Moser; Andrew S. Bae; James R. Prudent; Michael D. Miller; Katyna Borroto-Esoda;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Allele-Specific Real-Time PCR System for Detection of Subpopulations of Genotype 1a and 1b Hepatitis C NS5B Y448H Mutant Viruses in Clinical Samples [J] . Andrew S. Bae, Karin S. Ku, Michael D. Miller, Journal of Clinical Microbiology . 2011,第9期

机译：用于检测临床样本中基因型1a和1b丙型肝炎NS5B Y448H突变病毒亚群的等位基因特异性实时PCR系统
2. Replication-dependent 65R→K reversion in human immunodeficiency virus type 1 reverse transcriptase double mutant K65R + L74V [J] . Prem L. Sharma, Viktoria Nurpeisov, Kimberly Lee, Virology . 2004,第2期

机译：人类免疫缺陷病毒1型逆转录酶双突变体K65R + L74V中依赖复制的65R→K还原
3. Development of a pan-Simbu real-time reverse transcriptase PCR for the detection of Simbu serogroup viruses and comparison with SBV diagnostic PCR systems [J] . Melina Fischer, Horst Schirrmeier, Kerstin Wernike, Virology Journal . 2013,第1期

机译：泛Simbu实时逆转录酶PCR的开发，用于检测Simbu血清群病毒并与SBV诊断PCR系统进行比较
4. Simultaneous extraction of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) RNA with the M1000 apparatus does not impair the measurement of the viral load of both viruses when tested by using the LCx PCR system [C] . T. Bourlet, S. Thamm, S. Pillet, European Congress of Virology . 2004

机译：通过使用LCX PCR系统测试，同时提取人免疫缺陷病毒类型1（HIV-1）和丙型肝炎病毒（HCV）RNA，不会损害两种病毒的病毒载量的测量
5. Biochemical characterization of human immunodeficiency virus type 1 reverse transcriptase mutants to non-nucleoside reverse transcriptase inhibitors [D] . Domaoal, Robert A. 2005

机译：人类免疫缺陷病毒1型逆转录酶突变体对非核苷类逆转录酶抑制剂的生化特性
6. MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples [O] . Evguenia S. Svarovskaia, Michael J. Moser, Andrew S. Bae, 2006

机译：用于检测临床样品中K65R人类免疫缺陷病毒1型逆转录酶突变病毒亚群的MultiCode-RTx实时PCR系统
7. MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples▿ [O] . Svarovskaia, Evguenia S., Moser, Michael J., Bae, Andrew S., 2006

机译：用于检测临床样品中K65R人类免疫缺陷病毒1型逆转录酶突变病毒亚群的MultiCode-RTx实时PCR系统▿

MultiCode-RTx Real-Time PCR System for Detection of Subpopulations of K65R Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant Viruses in Clinical Samples

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