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首页> 外文期刊>Journal of Clinical Microbiology >Analysis of Echovirus 30 Isolates from Russia and New Independent States Revealing Frequent Recombination and Reemergence of Ancient Lineages
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Analysis of Echovirus 30 Isolates from Russia and New Independent States Revealing Frequent Recombination and Reemergence of Ancient Lineages

机译:分析来自俄罗斯和新独立国家的Echovirus 30分离株,揭示了古代血统的频繁重组和重新出现

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We studied two genome regions, VP1 and 3D, of 48 echovirus 30 (E30) isolates from Russia and the new independent states. In VP1, most isolates were similar to European strains reported earlier, and frequent change of circulating subgroups was noticed. We also observed, in 2003-2006, the reemergence of a group of E30 strains with a VP1 region very distant from most modern E30 strains and remotely similar to E30 isolates from the 1960s and the 1970s. A study of the 3D genome region detected multiple recombination events among the studied strains. Recombination presumably occurred every few years, and therefore, the study of a single VP1 genome region cannot accurately describe the phylogenetic history of the virus or predict pathogenetic properties of an isolate. In general, a comparison of the VP1 and 3D genome region phylogenies revealed, in some instances, virtually independent circulation of enterovirus genome fragments on a scale of years.
机译:我们研究了来自俄罗斯和新独立国家的48个回声病毒30(E30)分离株的两个基因组区域VP1和3D。在VP1中,大多数分离株与先前报道的欧洲菌株相似,并且注意到循环亚组的频繁变化。我们还观察到,在2003-2006年间,出现了一组VP1区的E30菌株的出现,该菌株与大多数现代E30菌株相距甚远,并且与1960年代和1970年代的E30分离株非常相似。对3D基因组区域的研究检测到了所研究菌株之间的多个重组事件。重组可能每隔几年发生一次,因此,对单个VP1基因组区域的研究无法准确描述病毒的系统发生历史或预测分离株的致病特性。通常,对VP1和3D基因组区域系统发育的比较表明,在某些情况下,肠道病毒基因组片段实际上是在数年内独立循环的。

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