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首页> 外文期刊>Journal of Clinical Microbiology >Prevalence and Clinical Characterization of a Newly Identified Human Rhinovirus C Species in Children with Acute Respiratory Tract Infections
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Prevalence and Clinical Characterization of a Newly Identified Human Rhinovirus C Species in Children with Acute Respiratory Tract Infections

机译：急性呼吸道感染儿童中新鉴定的人类鼻病毒C种类的患病率和临床特征

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Human rhinovirus C (HRV-C) is a newly identified genotype of HRV found in patients with respiratory tract infections (RTIs); however, its epidemiological profile and clinical characteristics are not well understood. In this study, Chinese children with RTIs were screened for HRV-C and their epidemiological and clinical characteristics were analyzed. From December 2006 to November 2007, 406 nasopharyngeal aspirates from children younger than 14 years of age with RTIs were screened for HRV and other common respiratory viruses by PCR or reverse transcription-PCR. Two-hundred twenty-four (55.2%) of the specimens were infected with at least one virus, including 53 patients with HRV (13%). HRV-A, HRV-B, and HRV-C were detected in 22, 12, and 19 specimens, respectively. HRV-C was detected mainly from December 2006 to April 2007 and from October to November 2007, with peaks in December and April (10/19). Acute upper respiratory infection and bronchopneumonia were observed in 53 and 37% of the cases, respectively. The most common symptoms were cough (82%), runny nose (53%), and fever (37%). Wheezing and bronchiolitis were less common in patients infected with HRV-C than in those infected with respiratory syncytial virus (RSV). Partial sequencing of the genes coding for VP4 and VP2 revealed that the HRV-C strains were 56 to 62% identical at the amino acid level to HRV-B and HRV-A reference strains and 80 to 99% identical to HRV-C reference strains. In conclusion, HRV-C is an important cause of RTIs in children, and highly diversified strains of HRV-C are prevalent in China. HRV-C may produce different epidemiological features, and patients infected with HRV-C may exhibit different clinical features from patients infected with RSV or HRV-A/B.
机译：人类鼻病毒C（HRV-C）是呼吸道感染（RTIs）患者中新发现的HRV基因型。但是，其流行病学特征和临床特征尚不十分清楚。在这项研究中，对中国患有RTI的儿童进行了HRV-C筛查，并对其流行病学和临床特征进行了分析。从2006年12月至2007年11月，通过PCR或逆转录PCR技术对RTIs年龄在14岁以下的儿童的406例鼻咽吸出液进行了HRV和其他常见呼吸道病毒的筛查。二十四分（55.2％）的标本中至少感染了一种病毒，包括53例HRV患者（13％）。在22、12和19个样本中分别检测到HRV-A，HRV-B和HRV-C。主要在2006年12月至2007年4月以及2007年10月至2007年11月检测到HRV-C，并在12月和4月（10/19）达到峰值。分别在53％和37％的病例中观察到急性上呼吸道感染和支气管肺炎。最常见的症状是咳嗽（82％），流鼻涕（53％）和发烧（37％）。与感染呼吸道合胞病毒（RSV）的患者相比，感染HRV-C的患者的喘息和细支气管炎较少见。编码VP4和VP2的基因的部分测序显示，HRV-C菌株在氨基酸水平上与HRV-B和HRV-A参考菌株相同，为56％至62％，与HRV-C参考菌株相同，为80％至99％。 。总之，HRV-C是引起儿童RTI的重要原因，HRV-C的高度多样化菌株在中国很普遍。 HRV-C可能产生不同的流行病学特征，感染HRV-C的患者可能表现出与感染RSV或HRV-A / B的患者不同的临床特征。

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