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首页> 外文期刊>Journal of Clinical Microbiology >Evaluation of Dry and Wet Transported Intravaginal Swabs in Detection of Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Female Soldiers by PCR
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Evaluation of Dry and Wet Transported Intravaginal Swabs in Detection of Chlamydia trachomatis and Neisseria gonorrhoeae Infections in Female Soldiers by PCR

机译：PCR评价干湿两用阴道拭子检测女兵沙眼衣原体和淋病奈瑟菌感染的效果

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Screening women for sexually transmitted diseases (STD) in nonclinic settings is highly desirable because many infections are asymptomatic. This is especially true for military women, for whom logistical, social, and other job-related obstacles present barriers to accessing medical care. We assessed the accuracy of intravaginal swabs transported by mail in a wet versus a dry state for PCR (Amplicor CT/NG test) detection of chlamydia and gonorrhea infections in a cross-sectional study of 793 active-duty military women attending an STD clinic. PCR tests of vaginal swabs (wet and dry) were compared to local clinical methods used on cervical swabs. Standard wet vaginal swab PCR testing detected more chlamydia (11.6%) than cervical enzyme immunoassay (9.3%). For detection of chlamydia using wet swabs, the sensitivity and specificity compared with adjudicated true positives were 94.6% (87 of 92) and 99.3% (696 of 701), respectively. Comparing dry swabs to true-positives for chlamydia, the sensitivity was 91.3% (84 of 92) and the specificity was 99.3% (696 of 701). Standard wet vaginal swab PCR detected more gonorrhea (3.3%) than routine cervical culture (2.1%). The sensitivity and specificity of PCR testing of wet swabs compared to true-positives (infected patients) were 96.3% (26 of 27) and 98.2% (752 of 766) for gonorrhea, respectively. For gonorrhea, the sensitivity and specificity of dry swabs compared to true-positives (infected patients) were 88.9% (24 of 27) and 98.3% (753 of 766), respectively. PCR testing of wet and dry transported intravaginal swabs to detect chlamydia and gonorrhea infections was an accurate diagnostic method for military women.
机译：由于许多感染是无症状的，因此非常需要在非诊所环境中对妇女进行性传播疾病（STD）筛查。对于军事妇女来说尤其如此，因为她们的后勤，社会和其他与工作有关的障碍构成了获得医疗服务的障碍。在一项对793名在性病门诊就职的现役军人进行的横断面研究中，我们评估了湿状态和干燥状态下通过邮件运输的阴道拭子用于衣原体和淋病感染的PCR（扩增子CT / NG测试）检测的准确性。将阴道拭子（湿和干）的PCR测试与宫颈拭子上使用的本地临床方法进行了比较。标准的湿阴道拭子PCR测试检测到的衣原体感染（11.6％）比宫颈酶免疫检测（9.3％）多。对于使用湿拭子检测衣原体，与经判定的真阳性相比，其敏感性和特异性分别为94.6％（92个中的87个）和99.3％（701个中的696个）。将拭子与衣原体的真实阳性结果进行比较，敏感性为91.3％（92个中的84个），特异性为99.3％（701个中的696个）。标准的湿阴道拭子PCR检测到的淋病（3.3％）比常规宫颈培养的多（2.1％）。与淋巴结炎相比，与真正阳性（感染患者）相比，湿拭子PCR检测的敏感性和特异性分别为96.3％（27中的26）和98.2％（766中的752）。对于淋病，与真阳性（感染患者）相比，干拭子的敏感性和特异性分别为88.9％（27个中的24个）和98.3％（766个中的753个）。对干湿运输的阴道拭子进行PCR检测以检测衣原体和淋病感染是军事女性的准确诊断方法。

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