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首页> 外文期刊>Journal of Clinical Microbiology >Clonal Dissemination of Staphylococcus epidermidis in an Oncology Ward
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Clonal Dissemination of Staphylococcus epidermidis in an Oncology Ward

机译：表皮葡萄球菌在肿瘤病房中的克隆传播

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Coagulase-negative staphylococci (CoNS) are the main cause of catheter-related infections, especially among immunosuppressed and neutropenic patients, as well as a source of bacterial contamination in blood cultures. Using biochemical identification and pulsed-field gel electrophoresis (PFGE), we sought to identify possible clonal isolates of bacteremia in patients with central lines in an oncology ward (OW), with comparison to isolates that were recovered by venipuncture from an adult emergency room (ER). A total of 243 CoNS isolates were identified to species level from the OW (126) and ER (117), with Staphylococcus epidermidis isolates being the most common (OW, 79.4%; ER, 45.3%). PFGE demonstrated a predominant clone of S. epidermidis (major subtype A) which was 35.5 times more likely (odds ratio [OR] = 35.5; 95% confidence interval [CI] = 4.7 to 267.0; P < 0.00001) to be present in the OW versus the ER. These (CoNS or major subtype A) isolates were more frequently resistant to gentamicin (OR = 2.83; 95% CI = 1.23 to 6.53; P = 0.016) and less frequently resistant to trimethoprim-sulfamethoxazole (OR = 0.38; 95% CI = 0.18 to 0.80; P = 0.013). Subset analysis of S. epidermidis isolates 2 years after the study period showed the persistence of the clone of major subtype A within the OW. This study demonstrates the presence of a predominant clone among central line isolates from an OW that is not present in CoNS venipuncture isolates from an ER.
机译：凝固酶阴性葡萄球菌（CoNS）是导管相关感染的主要原因，尤其是在免疫抑制和中性粒细胞减少的患者中，以及血液培养中细菌污染的来源。使用生化鉴定和脉冲场凝胶电泳（PFGE），我们试图确定在肿瘤病房（OW）中线的患者中可能存在的菌血症的克隆分离株，与通过静脉穿刺从成人急诊室回收的分离株进行比较（ ER）。在OW（126）和ER（117）中共鉴定到243种CoNS分离株，其中以表皮葡萄球菌最常见（OW，79.4％; ER，45.3％）。 PFGE证明了 S的主要克隆。表皮动物（A类主要亚型）的可能性要高35.5倍（赔率[OR] = 35.5; 95％置信区间[CI] = 4.7至267.0; P <0.00001）存在于OW与ER中。这些（CoNS或主要的亚型A）分离株对庆大霉素的耐药性更高（OR = 2.83; 95％CI = 1.23至6.53; P = 0.016），对甲氧苄啶-磺胺甲基异恶唑的耐药性较弱（OR = 0.38; 95％CI = 0.18至0.80; P = 0.013）。 S的子集分析。研究期2年后分离出表皮动物，表明OW内主要A亚型克隆的持久性。这项研究表明在OW的中心线分离株中存在一个主要克隆，而ER的CoNS静脉穿刺分离株中不存在该克隆。

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