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首页> 外文期刊>Journal of Clinical Microbiology >DNA-Level Diversity and Relatedness of Helicobacter pylori Strains in Shantytown Families in Peru and Transmission in a Developing-Country Setting
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DNA-Level Diversity and Relatedness of Helicobacter pylori Strains in Shantytown Families in Peru and Transmission in a Developing-Country Setting

机译：秘鲁棚户区家庭幽门螺杆菌菌株的DNA水平多样性和相关性以及在发展中国家的传播

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The efficiency of transmission of a pathogen within families compared with that between unrelated persons can affect both the strategies needed to control or eradicate infection and how the pathogen evolves. In industrialized countries, most cases of transmission of the gastric pathogen Helicobacter pylori seems to be from mother to child. An alternative model, potentially applicable among the very poor in developing countries, where infection is more common and the sanitary infrastructure is often deficient, invokes frequent transmission among unrelated persons, often via environmental sources. In the present study, we compared the genotypes of H. pylori from members of shantytown households in Peru to better understand the transmission of H. pylori in developing-country settings. H. pylori cultures and/or DNAs were obtained with informed consent by the string test (a minimally invasive alternative to endoscopy) from at least one child and one parent from each of 62 families. The random amplified polymorphic DNA fingerprints of 57 of 81 (70%) child-mother strain pairs did not match, nor did the diagnostic gene sequences (>1% DNA sequence difference), independent of the child's age (range, 1 to 39 years). Most strains from siblings or other paired family members were also unrelated. These results suggest that H. pylori infections are often community acquired in the society studied. Transmission between unrelated persons should facilitate the formation of novel recombinant genotypes by interstrain DNA transfer and selection for genotypes that are well suited for individual hosts. It also implies that the effective prevention of H. pylori infection and associated gastroduodenal disease will require anti-H. pylori measures to be applied communitywide.
机译：家庭中病原体传播的效率与无亲属之间的传播效率相比，既会影响控制或消除感染所需的策略，又会影响病原体的进化。在工业化国家，胃病原体幽门螺杆菌的大多数传播病例似乎是由母亲传给孩子的。替代模式可能适用于感染较普遍且卫生基础设施通常很贫乏的发展中国家的极贫困国家，这种模式经常导致无关人员之间经常通过环境来源传播。在本研究中，我们比较了 H的基因型。来自秘鲁棚户区成员的幽门螺杆菌，以更好地了解 H的传播。幽门螺杆菌 H。幽门螺杆菌培养物和/或DNA是在62个家庭中的至少一个孩子和一个父母的情况下，通过字符串测试（内镜的微创替代方法）在知情同意下获得的。不依赖于儿童年龄（1至39岁）的81个（70％）儿童-母亲菌株对中的57个（随机数）多态性DNA指纹图谱不匹配，诊断基因序列（> 1％DNA序列差异）也不匹配）。来自兄弟姐妹或其他成对家庭成员的大多数菌株也不相关。这些结果表明 H。幽门螺杆菌感染通常是在所研究的社会中获得的社区。无关人员之间的传播应通过菌株间DNA转移和选择适合个体宿主的基因型来促进新的重组基因型的形成。这也意味着有效预防 H。幽门螺杆菌感染和相关的胃十二指肠疾病将需要抗 H。幽门螺杆菌措施将在整个社区中应用。

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