Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing

Ruiru Shi; Jianyuan Zhang; Chuanyou Li; Yuko Kazumi; Isamu Sugawara

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Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing

机译：变性高压液相色谱法和DNA测序法测定gyrA突变分析确定的中国结核分枝杆菌临床分离株对氧氟沙星的耐药性

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A high rate of double point mutations in gyrA (56% of 87 ofloxacin-resistant Mycobacterium tuberculosis clinical isolates) indicates the emergence of fluoroquinolone resistance. This is the first report to describe denaturing high-pressure liquid chromatography analysis of mutations in gyrA of M. tuberculosis in a large number of clinical isolates.

机译： gyrA 中双点突变的发生率很高（87种耐氧氟沙星的结核分枝杆菌临床分离株中有56％）表明氟喹诺酮耐药性的出现。这是描述变性 M的gyrA 中突变的变性高压液相色谱分析的第一份报告。大量临床分离物中的结核病。 展开▼

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《Journal of Clinical Microbiology》 |2006年第12期|共3页

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Ruiru Shi; Jianyuan Zhang; Chuanyou Li; Yuko Kazumi; Isamu Sugawara;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing [J] . Ruiru Shi, Jianyuan Zhang, Chuanyou Li, Journal of Clinical Microbiology . 2006,第12期

机译：变性高压液相色谱法和DNA测序法测定gyrA突变分析确定的中国结核分枝杆菌临床分离株对氧氟沙星的耐药性

2. Detection of streptomycin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by denaturing HPLC analysis and DNA sequencing. [J] . Shi R, Zhang J, Li C, Microbes and infection . 2007,第14a15期

机译：通过变性HPLC分析和DNA测序确定中国结核分枝杆菌临床分离株中链霉素抗性的检测。

3. Molecular detection of fluoroquinolone resistance-associated gyrA mutations in ofloxacin-resistant clinical isolates of Mycobacterium tuberculosis from Iran and Belarus [J] . Mohammad Arjomandzadegan, Leonid Titou, Parissa Tarma, International Journal of Mycobacteriology . 2016,第3期

机译：伊朗和白俄罗斯结核分枝杆菌耐药性临床分离株中氟喹诺酮耐药相关的gyrA突变的分子检测

4. Sequence Analysis of the Gene Region Encoding ESAT-6, Ag85B, and Ag85 C Proteins from Clinical Isolates of Mycobacterium tuberculosis [C] . Ni Made Mertaniasih, Didik Handijatno, Agnes Dwi Sis Perwitasari, International Seminar on Molecular and Cellular Life Sciences . 2016

机译：从结核分枝杆菌临床分离株编码ESAT-6，AG85B和AG85 C蛋白的基因区的序列分析

5. Data mining tool for correlating drug resistance with genomic mutations in Mycobacterium tuberculosis isolates [D] . Didulo, Dennis 2015

机译：关联结核分枝杆菌菌株耐药性与基因组突变的数据挖掘工具

6. Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing [O] . Ruiru Shi, Jianyuan Zhang, Chuanyou Li, 2006

机译：变性高压液相色谱法和DNA测序法测定gyrA突变分析确定的中国结核分枝杆菌临床分离株对氧氟沙星的耐药性

7. Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing▿ [O] . Shi, Ruiru, Zhang, Jianyuan, Li, Chuanyou, 2006

机译：变性高压液相色谱法和DNA测序法测定gyrA突变分析确定的中国结核分枝杆菌临床分离株对氧氟沙星的耐药性

1. 结核分枝杆菌耐氧氟沙星临床分离株gyrA基因突变的研究 [J] . 闫丽萍 ,肖和平 ,郑瑞娟 . 中国感染与化疗杂志 . 2010,第001期

2. 结核分枝杆菌对左氧氟沙星与莫西沙星的交叉耐药性及gyrA和gyrB基因突变分析 [J] . 李国利 ,陈澎 ,孙昌文 . 中国防痨杂志 . 2010,第010期

3. 98株河南省结核分枝杆菌氧氟沙星耐药株gyrA基因突变的研究 [J] . 赵玉玲 ,马晓光 ,李辉 . 中国人兽共患病学报 . 2012,第005期

4. 结核分枝杆菌耐喹诺酮临床分离株gyrA基因突变的研究 [J] . 安慧茹 ,王巍 ,李洪敏 . 中国防痨杂志 . 2004,第003期

5. 临床株鲍曼不动杆菌gyrA和parC突变与氟喹诺酮的耐药性及其突变风险因素分析 [J] . 刘辉 ,陈小东 ,黄浩南 . 医学理论与实践 . 2020,第020期

6. 结核分枝杆菌对左氧氟沙星与莫西沙星的交叉耐药性及gyrA和gyrB基因突变分析 [C] . 李国利 ,陈澎 ,孙昌文 . 2010年中国防痨协会临床/基础专业学术大会 . 2010

7. 青岛地区幽门螺杆菌对左氧氟沙星耐药性及gyrA基因突变分析 [A] . 王松松 . 2013

1. 新疆地区的结核分枝杆菌临床分离株中存在PhoP基因的天然缺失突变菌株 [P] . 中国专利： CN109810932A . 2019-05-28

2. Method for isolating DNA of clinical isolates of Mycobacterium tuberculosis from lung tissue [P] . 外国专利： RU2016129359A . 2018-01-23

机译：从肺组织中分离结核分枝杆菌临床分离株的DNA的方法

3. Method for simultaneous detection of Mycobacterium tuberculosis complex and identification of mutations in mycobacterial DNA resulting in the resistance of microorganisms to rifampicin and isoniazid on biological microarrays, set of primers, biochip, and set of oligonucleotide probes used in the method [P] . 外国专利： US2010261163A1 . 2010-10-14

机译：在生物微阵列上同时检测结核分枝杆菌复合物和鉴定导致微生物对利福平和异烟肼具有抗性的分枝杆菌DNA突变的方法，该方法中使用的引物组，生物芯片和寡核苷酸探针组

4. METHOD FOR SIMULTANEOUS DETECTION OF MYCOBACTERIUM TUBERCULOSIS COMPLEX AND IDENTIFICATION OF MUTATIONS IN MYCOBACTERIAL DNA RESULTING IN THE RESISTANCE OF MICROORGANISMS TO RIFAMPICIN AND ISONIAZID ON BIOLOGICAL MICROARRAYS, SET OF PRIMERS, BIOCHIP, AND SET OF OLIGONUCLEOTIDE PROBES USED IN THE METHOD [P] . 外国专利： IN2006DE02794A . 2007-08-31

机译：同时检测结核分枝杆菌结核复合物的方法和鉴定真菌DNA中突变的方法，其结果是微生物对利福平和异烟肼对生物微阵列，果胶，胶酶和蛋白质组的耐药性

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Emergence of Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates from China as Determined by gyrA Mutation Analysis Using Denaturing High-Pressure Liquid Chromatography and DNA Sequencing

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