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首页> 外文期刊>Journal of Clinical Microbiology >Molecular Epidemiology of Multidrug-Resistant Mycobacterium bovis Isolates with the Same Spoligotyping Profile as Isolates from Animals
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Molecular Epidemiology of Multidrug-Resistant Mycobacterium bovis Isolates with the Same Spoligotyping Profile as Isolates from Animals

机译：具有与动物分离物相同的血吸虫分型谱的多药耐药牛分枝杆菌分子流行病学

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摘要

PCR-based characterization techniques have been adopted in most laboratories for Mycobacterium bovis typing. We report a molecular characterization of human multidrug-resistant M. bovis isolates and three bovine isolates that share the spoligotyping profile. The analysis of the direct repeat region showed that both groups differed in the presence of spacers not included in the current membrane. They were also distinguished by two out of the nine mycobacterial interspersed repetitive unit variable-number tandem repeat loci tested, indicating that the human infection was not acquired from the cattle from which isolates were obtained. These results highlight that a combination of techniques is required for appropriate discrimination, even for those spoligotypes that have a low frequency.
机译：大多数实验室已采用基于PCR的表征技术进行牛分枝杆菌的分型。我们报告了人类多药耐药性 M的分子特征。 bovis 分离株和3个共有spoligotyping谱图的牛分离株。对直接重复区域的分析表明，两组的差异在于当前膜中未包含的间隔基的存在。它们还通过测试的9个分枝杆菌散布的重复单位可变数量串联重复基因座中的2个而区分，这表明人的感染并非来自获得分离株的牛。这些结果突出表明，即使对于那些频率较低的血吸虫型，也需要组合使用多种技术来进行适当的区分。

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