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首页> 外文期刊>Journal of Clinical Microbiology >Cervical Human Papillomavirus (HPV) Infection and HPV Type 16 Antibodies in South African Women
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Cervical Human Papillomavirus (HPV) Infection and HPV Type 16 Antibodies in South African Women

机译：南非妇女宫颈人乳头瘤病毒（HPV）感染和HPV 16型抗体

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There is a high incidence of cervical cancer in South African women. No large studies to assess human papillomavirus virus (HPV) infection or HPV type 16 (HPV-16) exposure have occurred in the region, a requirement for policy making with regards to HPV screening and the introduction of vaccines. Control women (n = 1,003) enrolled in a case control study of hormonal contraceptives and cervical cancer were tested for 27 cervical HPV types by reverse line blot analysis. The seroprevalence of HPV-16 immunoglobulin G (IgG) and IgA antibodies was assessed by a virus-like particle-based enzyme-linked immunoassay of 908 and 904 control women, respectively, and of 474 women with cervical cancer. The cervical HPV prevalence was 26.1%. The HPV-16 IgG seroprevalence was 44.4% and the HPV-16 IgA seroprevalence was 28.7% in control women, and these levels were significantly higher (61.8% and 52.7%, respectively) for women with cervical cancer (odds ratio [OR], 2.1 and 2.8, respectively). The cervical HPV prevalence showed an association with cervical disease, and the HPV-16 IgG prevalence decreased while the HPV-16 IgA prevalence increased with increasing age (P < 0.05). The prevalence of oncogenic HPV types (including HPV-16) decreased with age, whereas nononcogenic HPV types showed limited association with age. Multivariate analysis revealed cervical HPV infection to be associated with herpes simplex virus type 2 infection (OR, 1.7) and increasing years of education (OR, 1.9). HPV-16 IgG antibodies were inversely associated with current smoking status (OR, 0.6), and the presence of HPV-16 IgA antibodies was inversely associated with the use of alcohol (OR, 2.1) and inversely associated with the use of oral contraceptives (OR, 0.6). High levels of exposure to HPV, and particularly HPV-16, were evident in this population. The apparent increase of serum HPV-16 IgA with increasing age requires further investigation.
机译：南非妇女宫颈癌的发病率很高。该地区未进行评估人乳头瘤病毒（HPV）感染或16型HPV（HPV-16）暴露的大型研究，这是有关HPV筛查和疫苗接种的政策制定要求。参加激素避孕和宫颈癌病例对照研究的对照妇女（ n = 1,003）通过反向线印迹分析检测了27种宫颈HPV类型。 HPV-16免疫球蛋白G（IgG）和IgA抗体的血清阳性率分别通过908例和904例对照女性以及474例宫颈癌女性的基于病毒样颗粒的酶联免疫法进行评估。宫颈HPV患病率为26.1％。对照女性的HPV-16 IgG血清阳性率为44.4％，HPV-16 IgA血清阳性率为28.7％，宫颈癌女性的这些水平明显更高（分别为61.8％和52.7％）（几率[OR]， 2.1和2.8）。宫颈HPV流行与宫颈疾病相关，HPV-16 IgG流行随着年龄的增长而降低，而HPV-16 IgA流行随着年龄的增长而增加（ P <0.05）。致癌HPV类型（包括HPV-16）的患病率随年龄下降，而非致癌HPV类型与年龄的关联性有限。多变量分析显示宫颈HPV感染与单纯疱疹病毒2型感染（OR，1.7）和受教育年限增加（OR，1.9）有关。 HPV-16 IgG抗体与当前吸烟状况成反比（OR，0.6），HPV-16 IgA抗体的存在与饮酒成反比（OR，2.1）和与口服避孕药成反比（（或0.6）。在该人群中明显暴露于高水平的HPV，尤其是HPV-16。随着年龄的增长，血清HPV-16 IgA的明显增加需要进一步研究。

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