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首页> 外文期刊>Journal of Clinical Microbiology >Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002
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Genotypic Comparison of Invasive Neisseria meningitidis Serogroup Y Isolates from the United States, South Africa, and Israel, Isolated from 1999 through 2002

机译：从1999年至2002年分离的美国，南非和以色列的侵袭性脑膜炎奈瑟氏球菌血清型Y分离株的基因型比较

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The proportion of meningococcal disease in the United States, South Africa, and Israel caused by Neisseria meningitidis serogroup Y (NmY) was greater than the worldwide average during the period 1999-2002. Genotypic characterization of 300 NmY isolates by multilocus sequence typing, 16S rRNA gene sequencing, and PorA variable region typing was conducted to determine the relationships of the isolates from these three countries. Seventy different genotypes were found. Two groups of ST-23 clonal complex isolates accounted for 88% of the U.S. isolates, 12% of the South African isolates, and 96% of the isolates from Israel. The single common clone (ST-23/16S-19/P1.5-2,10-1) represented 57, 5, and 35% of the NmY isolates from the United States, South Africa, and Israel. The predominant clone in South Africa (ST-175/16S-21/P1.5-1,2-2), and 11 other closely related clones made up 77% of the South African study isolates and were not found among the isolates from the United States or Israel. ST-175 was the predicted founder of the ST-175 clonal complex, and isolates of ST-175 and related sequence types have been described previously in other African countries. Continued active surveillance and genetic characterization of NmY isolates causing disease in the United States, South Africa, and Israel will provide valuable data for local and global epidemiology and allow monitoring for any expansion of existing clonal complexes and detection of the emergence of new virulent clones in the population.
机译：在1999年至2002年期间，在美国，南非和以色列由脑膜炎奈瑟氏球菌（YmY）血清群Y（NmY）引起的脑膜炎球菌疾病所占比例高于世界平均水平。通过多基因座序列分型，16S rRNA基因测序和PorA可变区分型对300个NmY分离株进行了基因型鉴定，以确定这三个国家的分离株之间的关系。发现了七十个不同的基因型。两组ST-23克隆复合物分离株占美国分离株的88％，南非分离株的12％和来自以色列的分离株的96％。单个常见克隆（ST-23 / 16S-19 / P1.5-2,10-1）分别代表了来自美国，南非和以色列的NmY分离株的57％，5％和35％。南非的主要克隆（ST-175 / 16S-21 / P1.5-1,2-2）和其他11个密切相关的克隆占南非研究分离株的77％，在来自非洲的分离株中未发现美国或以色列。 ST-175是ST-175克隆复合体的预计创建者，并且ST-175的分离株和相关序列类型先前已在其他非洲国家中进行过描述。在美国，南非和以色列继续对引起疾病的NmY分离株进行主动监测和遗传鉴定，将为当地和全球流行病学提供有价值的数据，并允许监测现有克隆复合体的任何扩展并检测新的有毒克隆。人口。

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