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首页> 外文期刊>Journal of Clinical Microbiology >Emergence of New CMRSA7/USA400 Methicillin-Resistant Staphylococcus aureus spa Types in Alberta, Canada, from 2005 to 2012
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Emergence of New CMRSA7/USA400 Methicillin-Resistant Staphylococcus aureus spa Types in Alberta, Canada, from 2005 to 2012

机译：2005年至2012年在加拿大艾伯塔省出现的新型CMRSA7 / USA400耐甲氧西林金黄色葡萄球菌spa类型

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Methicillin-resistant Staphylococcus aureus (MRSA) has become one of the most significant pathogens affecting global public health and health care systems. In Canada and the United States, the spread of MRSA is primarily attributed to a single dominant epidemic clone: CMRSA10/USA300. Despite this, the CMRSA7/USA400 epidemic clone has been reported to be the predominate epidemic clone in several Canadian provinces and some parts of the United States. This study examined the epidemiology of CMRSA7/USA400 MRSA in Alberta, Canada, from June 2005 to December 2012. Molecular characterization of CMRSA7/USA400 isolates was done using spa, SCCmec, PVL, and PFGE typing and identified two predominant spa types in Alberta: t128 and t1787. Although closely related, these spa types have distinct geographic distributions. From 2010 to 2012, the number of t128 infections has remained stable while there has been a nearly 3-fold increase in the number of provincial t1787 infections, accompanied by 10-fold increases in t1787 infection rates in some communities. Most t128 and t1787 patients were First Nations or Inuit people, and isolates were usually from skin and soft tissue infections in outpatients. t128 patients were significantly older than t1787 patients. Antimicrobial susceptibility testing showed higher mupirocin resistance in t1787 than in t128 MRSA. Improved strategies to reduce or stabilize t1787 infections in Alberta are needed.
机译：耐甲氧西林金黄色葡萄球菌（MRSA）已成为影响全球公共卫生和卫生保健系统的最重要病原体之一。在加拿大和美国，MRSA的传播主要归因于单一的主要流行性克隆：CMRSA10 / USA300。尽管如此，在加拿大的几个省和美国的某些地区，据报道CMRSA7 / USA400流行克隆仍是流行的克隆。这项研究调查了2005年6月至2012年12月在加拿大艾伯塔省CMRSA7 / USA400 MRSA的流行病学。使用 spa ，SCC mec 对CMRSA7 / USA400分离株进行了分子鉴定。 ，PVL和PFGE的类型，并在艾伯塔省确定了两种主要的 spa 类型：t128和t1787。尽管这些密切相关，但这些 spa 类型具有独特的地理分布。从2010年到2012年，t128感染数保持稳定，而省级t1787感染数增加了近3倍，同时某些社区的t1787感染率增加了10倍。大多数t128和t1787患者是原住民或因纽特人，而分离株通常来自门诊患者的皮肤和软组织感染。 t128患者的年龄明显大于t1787患者。抗菌药敏试验显示，t1787中的莫匹罗星耐药性高于t128 MRSA。需要减少或稳定艾伯塔省t1787感染的改进策略。

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